Skip to main content
OpenTrials
Completed

NCT Number: NCT02758470

Muscle Fatigue and Carbonic Anhydrase Inhibitors

The objective of this research is to assess the effects of acetazolamide and methazolamide on respiratory and limb muscle fatigue development. A fatiguing protocol will be conducted for the respiratory and plantar flexor muscles and the difference in pressure/torque produced by supramaximal nerve stimulation used to assess muscle fatigue between conditions.

Completed

Looking for future studies?

Notify Me

Key information

Conditions

Hypoxia Pathological Conditions, Signs and Symptoms Signs and Symptoms Signs and Symptoms, Respiratory

Age range

18 year–40 year

Sex eligibility

Male

Study type

Interventional

Phase

Phase 4

Primary location

University of British Columbia

Kelowna, British Columbia, V1V 1V7, Canada

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Age: 18-40 years.
  • Regularly physically active
  • Male

Exclusion criteria

  • current or ex-smokers
  • pulmonary function <80% of predicted
  • esophageal tumour or ulcer
  • have had recent (<6 months) musculoskeletal injury or any surgery to the lower leg
  • have contraindications to carbonic anhydrase inhibitors (eg. severe or absolute glaucoma, adrenocortical insufficiency, hepatic insufficiency, renal insufficiency, sulfa allergy or an electrolyte imbalance such as hyperchloremic acidosis)
  • are obese (BMI >30 Kg/m2)
  • taking diuretics, blood thinners, or anti-platelet drugs.

Treatment and study plan

Acetazolamide

Drug

250 mg, taken orally three times per day

Methazolamide

Drug

100mg, taken orally two times per day. A placebo pill will be taken between each dose of methazolamide to match the timing of doses and the number of pills between study arms.

Placebo

Other

A placebo will be taken three times per day

Primary outcomes

  1. Change in trans-diaphragmatic pressure generation to supramaximal phrenic nerve stimulation following inspiratory threshold loading.

    Time frame: Baseline, 1, 5, 10, 20, and 30 minutes following the loading protocol for each arm of the study

  2. Change in plantar flexor muscle group torque generation to supramaximal tibial nerve stimulation following an isometric loading protocol

    Time frame: Baseline, 1, 5, 10, 20, and 30 minutes following the loading protocol for each arm of the study

Secondary outcomes

  1. Maximal inspiratory pressure maneuvers

    Time frame: Baseline and immediately following loading protocol

  2. Maximal Voluntary Contraction of the Plantar Flexor Muscle Group

    Time frame: Baseline and immediately following the loading protocol

  3. Contraction time and half-relaxation time

    Time frame: Baseline, 1, 5, 10, 20, and 30 minutes post loading protocol

Other outcomes

  1. Esophageal and Gastric Pressure

    Time frame: Baseline, 1, 5, 10, 20, and 30 minutes post loading protocol

  2. Heart Rate

    Time frame: Baseline, 1, 5, 10, 20, and 30 minutes post loading protocol

  3. Beat-by-beat blood pressure

    Time frame: Baseline, 1, 5, 10, 20, and 30 minutes post loading protocol

Sponsors and collaborators

Lead sponsor

University of British Columbia

Other

Registry information

Official study title

The Effect of Carbonic Anhydrase Inhibitors on the Pulmonary System Response to Muscle Fatigue.

Important dates

Study start
2016
Primary completion
2017
Study completion
2017
First posted
May 2, 2016
Registry last updated
Sep 25, 2018

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Related clinical trials

Published trials that share one or more normalized conditions with this study.