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NCT Number: NCT06654986

Muscle Anabolic Response to β2-adrenergic Stimulation With Increased Amino Acid Availability.

The purpose of the project is to investigate the effect of amino acid availability on the muscle anabolic response to beta2-adrenergic stimulation in young healthy men and women.

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Key information

Conditions

Healthy

Age range

18 year–40 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

August Krogh Building

Copenhagen, 2100, Denmark

Location status: Recruiting

Location contact

Morten Hostrup, PhD

CONTACT

[email protected]

+4535321595

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Age 18-40
  • Physically active >5 hours a week
  • Maximum oxygen uptake classified as high or very high

Exclusion criteria

  • Active smoker currently or within the past 5 years
  • Regular intake of medication deemed by the responsible study physician to affect the test parameters (hormonal contraception is accepted for women)
  • Chronic or acute illness deemed by the responsible study physician to affect the test parameters
  • Deviation from the study protocol
  • Lean mass index >21 kg/m²
  • Pregnancy
  • Smoker
  • Blood donation during the past 3 months

Treatment and study plan

Salmeterol + amino acid availability

Drug

The participants will be administered 200 µg salmeterol (8 puffs) from a MDI device and 40 g amino acid availability (clear whey in a shaker with water) daily during a 6-week intervention. Participants will be instructed to provide documentation of both the inhalation and the shaker intake via video.

Salmeterol + placebo

Drug

The participants will be administered 200 µg salmeterol (8 puffs) from a MDI device. Furthermore they will be administered 80 g placebo (carbo fuel in a shaker with water) daily during a 6-week intervention. Participants will be instructed to provide documentation of both the inhalation and the shaker intake via video.

Placebo + Placebo

Drug

The participants will be administered placebo (8 puffs) from a MDI device. Furthermore they will be administered 80 g placebo (carbo fuel in a shaker with water) daily during a 6-week intervention. Participants will be instructed to provide documentation of both the inhalation and the shaker intake via video.

Primary outcomes

  1. Skeletal muscle hypertrophy

    Time frame: Through study completion, an average on 7 weeks

    Muscle hypertrophy measured using Dual-energy X-ray Absorptiometry (DXA).

Secondary outcomes

  1. Quadriceps strength

    Time frame: Through study completion, an average on 7 weeks

    Maksimal torque (Nm) achieved during isometric contraction

  2. Power output during sprint testing

    Time frame: Through study completion, an average on 7 weeks

    Power output measured in Watts during a sprint on a bike ergometer

  3. Power output during time trial

    Time frame: Through study completion, an average on 7 weeks

    Mean power output measured in Watts during a time trial on a bike ergometer

Other outcomes

  1. Maximal oxygen uptake

    Time frame: Through study completion, an average on 7 weeks

    Maximal oxygen uptake measured during an incremental test to exhaustion on a bike ergometer.

Sponsors and collaborators

Lead sponsor

University of Copenhagen

Other

Registry information

Official study title

The Importance of Amino Acid Availability in Modulating the Muscle Anabolic Response to β2-adrenergic Stimulation.

Important dates

Study start
2024
Primary completion
2026
Study completion
2026
First posted
Oct 23, 2024
Registry last updated
Apr 9, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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