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NCT Number: NCT05870033

Muscle Activation in Knee Osteoarthritis

Muscle activity, as a possible fundamental cause of functional limitation, has been extensively investigated in knee osteoarthritis (KOA). Many trials investigated muscle activity during dynamic movements and functional tasks in KOA. In addition, gender-related differences has been also investigated during functional movements in KOA. However, no trial investigated gender-related differences in muscle activation during static movement in KOA.

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Key information

Conditions

Knee Osteoarthritis Arthritis Joint Diseases Musculoskeletal Diseases Osteoarthritis Osteoarthritis, Knee Rheumatic Diseases

Age range

60 year–75 year

Sex eligibility

All sexes

Study type

Observational

Primary location

University of Pécs

Pécs, Baranya, 7621, Hungary

About this study

Muscle activity, as a possible fundamental cause of functional limitation, has been extensively investigated in knee osteoarthritis (KOA). Interestingly, studies concentrated mainly on investigation of muscle activity during dynamic movements and different functional tests. Moznuzzaman et al displayed greater muscle activation during sitting to standing test (STS) and standing to sitting test in KOA patients compared to healthy participants. Interestingly, some studies investigated muscle activation standing up from a knee-height seat during STS and illustrated a greater muscle activation amongst KOA patients compared to healthy controls. Moreover, Amer et al found greater muscle activation while performing STS from a lower height seat compared to a knee-height seat amongst women and men patients with uni/bilateral KOA. These findings might be of interest due to compensatory mechanisms observed by female patients during STS transition increases loading on the joint surfaces and consequently leading to progression of KOA. Furthermore, different studies also presented gender-differences of muscle activation during different weight-bearing tasks (gait, STS, stair ascend/descend, and squat) amongst patients with KOA and healthy control. Interestingly, both studies showed women with KOA representing higher muscle activation compared to men. Therefore, an analytical comparative study might be useful for identification of gender-differences in muscle activation amongst patients with KOA.

Investigation of static muscle activity during functional movements is very rare in KOA. Zhang et al investigated muscle activation after single whole body vibration trial in standing position at 0°, 30° and 60° static knee flexion angles amongst women with KOA. Authors found that muscle activation in 60° was greater compared to 30°, and it was also greater in 30° compared to 0°. Based on our literature search, no further study examined muscle activity in static knee flexion in KOA. However, investigating static knee flexion might be useful as it could be related to different knee moments in KOA.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • radiologically diagnosed KOA based on the Kellgren-Lawrence grading system 1-3,
  • age above 60 years
  • at least 60° active knee flexion
  • sufficient mental status

Exclusion criteria

  • acute inflammation of the knee
  • intraarticular injections within the last 3 months
  • total knee replacement in the opposite side
  • class II obesity (body mass index, BMI>35kg/m2)
  • severe degenerative lumbar spine disease (e.g., spondylolisthesis)
  • systemic inflammatory arthritic or neurological condition
  • conservative intervention attendance within 6 months
  • contraindication to conservative therapy and manual therapy
  • unstable heart condition
  • complex regional pain syndrome

Treatment and study plan

Electromyography (EMG) measurement

Device

Electromyography (EMG) measurement of m. quadriceps femoris and semitendinosus muscle during static functional tasks

Primary outcomes

  1. Patients' baseline state

    Time frame: within 1 day

    Measurement of patients' pain, stiffness and functional state based on WOMAC

  2. Patients' baseline pain

    Time frame: within 1 day

    Measurement of patients' pain based on Numeric Pain Rating Scale

  3. Patients' baseline knee flexion

    Time frame: within 1 day

    Measurement of patients' active knee flexion in supine

  4. Patients' baseline knee flexion in standing position

    Time frame: within 1 day

    Measurement of patients' active knee flexion during weight-bearing

  5. Muscle strength of m. quadriceps femoris

    Time frame: within 1 day

    Measurement of muscle strength of m. quadriceps femoris in 0, 35 and 60 degree

  6. Muscle strength of hamstring muscles

    Time frame: within 1 day

    Measurement of muscle strength of m. semitendinosus, semimembranosus and biceps femoris in 0, 35 and 60 degree

  7. Muscle activation in 30 degree static knee flexion

    Time frame: within 1 day

    EMG measurement of muscle activation during 2-leg 30 degree static knee flexion

  8. Muscle activation in 60 degree static knee flexion

    Time frame: within 1 day

    EMG measurement of muscle activation during 2-leg 60 degree static knee flexion

  9. Muscle activation during stepping up a stair

    Time frame: within 1 day

    EMG measurement of muscle activation during stepping up on a stair

  10. Muscle activation during stepping down a stair

    Time frame: within 1 day

    EMG measurement of muscle activation during stepping down from a stair

  11. Muscle activation during stepping down side-ways a stair with affected leg

    Time frame: within 1 day

    EMG measurement of muscle activation during stepping down side-ways a stair with affected leg

  12. Muscle activation during stepping down side-ways a stair with opposite leg

    Time frame: within 1 day

    EMG measurement of muscle activation during stepping down side-ways a stair with opposite leg

  13. Muscle activation in one-leg standing position

    Time frame: within 1 day

    EMG measurement of muscle activation in one-leg standing position

Sponsors and collaborators

Lead sponsor

University of Pecs

Other

Registry information

Official study title

Gender Difference of Muscle Activation Amongst Patients With Knee Osteoarthritis

Important dates

Study start
2023
Primary completion
2023
Study completion
2023
First posted
May 23, 2023
Registry last updated
Dec 1, 2023

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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