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NCT Number: NCT06966206

Multiprofen-CC to Reduce Pain in Hand Arthritis

This clinical trial aims to find out if using 1 gram of Multiprofen-CC cream on the hands three times a day for 4 weeks can help reduce pain in adults with hand osteoarthritis, compared to a placebo (a cream with no active medicine). The research team will also look at how Multiprofen-CC affects hand function, opioid use, and how patients feel about their overall improvement. In addition, the research team will keep track of any side effects.

Participants will:

* Use both Multiprofen-CC and a placebo (a cream with no active medicine) during the study, in a random order. * Be asked to apply 1 gram of cream to their hands three times a day for 2 weeks, following the manufacturer's instructions. * Attend a visit before starting the study, after 2 weeks, and after 6 weeks. * Report any symptoms they experience during the study.

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Key information

Conditions

Hand Osteoarthritis Arthritis Joint Diseases Musculoskeletal Diseases Osteoarthritis Rheumatic Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Phase 3

Primary location

St. Joseph's Healthcare Hamilton

Hamilton, Ontario, L8N4A6, Canada

Location status: Recruiting

Location contact

Breanne Flood, MSc

CONTACT

[email protected]

9058701382

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Adults (18+)
  • Have been diagnosed with hand osteoarthritis according to American College of Rheumatology criteria
  • Experience pain and/or loss of function in one or both hands that interferes with daily life
  • Provide informed consent

Exclusion criteria

  • Unable to consent
  • Unable or unwilling to follow study protocol
  • Known allergy or contraindication to any of the study drugs or their ingredients
  • Have open wounds/cuts and/or skin conditions on the hand area
  • Pregnant or breastfeeding
  • History of impaired kidney or liver function
  • Rheumatoid or other inflammatory arthropathy
  • Hand surgery within the past 6 months or planned within the study period.
  • Use daily opioids (other than short acting codeine) for a chronic pain condition other than hand arthritis

Treatment and study plan

Multiprofen-CC™ plus standard treatment

Drug

Standard care pain medications and topical Multiprofen-CC™ (1g TID) for 2 weeks

Placebo plus standard treatment

Other

Standard care pain medications and visually identical topical placebo (1g TID) for 2 weeks

Primary outcomes

  1. Pain intensity

    Time frame: baseline [week 0] and weeks 2, 4, and 6

    Average pain intensity will be measured using a 0-10 Numeric Rating Scale (NRS), where 0 represents "no pain" and 10 represents "worst imaginable pain." Scores are collected before and after each treatment period. Higher scores indicate greater pain intensity and thus a worse outcome.

Secondary outcomes

  1. Hand function

    Time frame: weeks 2, 4 and 6

    Measured using the Michigan Hand Outcomes Questionnaire (MHQ), a validated instrument assessing hand function, activities of daily living, work performance, pain, aesthetics, and patient satisfaction. The total score ranges from 0 to 100, with higher scores representing better overall hand function and patient-reported outcomes.

  2. Patients reported improvement

    Time frame: weeks 2, 4 and 6

    Measured using the Patient Global Impression of Change (PGIC) scale, a single-item, patient-reported measure of overall improvement. The scale ranges from 1 to 7, where 1 indicates "very much improved" and 7 indicates "very much worse." Lower scores represent better outcomes.

  3. Safety - adverse events

    Time frame: through study completion, an average of 6 weeks

    Hand-related and medication-related serious and non-serious adverse events

Study contacts

Contact information is provided by the study sponsor or research team.

Breanne Flood, MSc

CONTACT

[email protected]

905-870-1382

Kim Irish, BSW

CONTACT

[email protected]

365-336-7598

Sponsors and collaborators

Lead sponsor

St. Joseph's Healthcare Hamilton

Other

Registry information

Official study title

Multiprofen-CC to Reduce Pain in Hand Arthritis (MRP-HAND): A Crossover Randomized Controlled Trial

Acronym: MRP-HAND

Important dates

Study start
2026
Primary completion
2026
Study completion
2027
First posted
May 11, 2025
Registry last updated
May 4, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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