Multiplex PCR for Severe Respiratory In… | Clinical Trial

Key information

Conditions

Viral Pneumonia Infections Lung Diseases Pneumonia Pneumonia, Viral Respiratory Tract Diseases Respiratory Tract Infections Virus Diseases

Sex eligibility

All sexes

Study type

Observational

Primary location

Schvoerer

Vandœuvre-lès-Nancy, 54511, France

About this study

The hypothesis was that a retrospective investigation of the molecular virological tests in a University hospital could be informative, with the aim to identify non-COVID-19 respiratory viruses during the circulation of SARS-CoV-2, according to systematic population data for public health knowledge:

the main goal was to perform a retrospective investigation of the molecular virological tests in a University hospital, in order to identify non-COVID-19 respiratory viruses from the beginning of 2021 to mid-2022 during the circulation of SARS-CoV-2, for public health knowledge;
the secondary aim was to retrospectively analyze, for a small subgroup of patients from an intensive care unit, the files of patients with positive molecular virological tests for non-COVID-19 respiratory viruses from the beginning of 2021 to mid-2022, reporting the following standard-of-care data: (i) the identification of the viruses, (ii) bioclinical features, (iii) medical impact of virological results in real life.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

For adult patients, or minors 'via' parents, able to give consent - 18 intensive care patients

Exclusion criteria

Non-inclusion in case of refusal

Treatment and study plan

other: Observational

Other

For 18 ICU patients, retrospective collection of routine bioclinical database (ICCA db)

Primary outcomes

Occurrence of positive viral PCR assays (not COVID-19) from hospitalizations for respiratory infections.

Time frame: 18 months, retrospectively

Number of patients with positive virological molecular tests (multiplex respiratory panels) from the beginning of 2021 to mid-2022, with the nature of the viruses detected and the chronology of occurrence of positive tests.

Secondary outcomes

Real-life features of patients in Intensive care (from the whole population - Outcome 1) with positive viral PCR during infectious pneumonia.

Time frame: 18 months, retrospectively
For the group of patients in Intensive Care:
- (i) number of positive molecular virological tests detecting respiratory viruses by FilmArray Pneumonia test
- (ii) associated bioclinical data
- (iii) medical impact of virological results in real life - progression of the infection and duration of thehospitalization.

Sponsors and collaborators

Lead sponsor

Central Hospital, Nancy, France

Other

Registry information

Official study title

Relevance of the Multiplex PCR Approach for Severe Respiratory Infections of Patients Hospitalized - Including an Intensive Care Unit, During the COVID-19 Pandemic

Acronym: VirCoV+

Important dates

Study start: 2024
Primary completion: 2024
Study completion: 2024
First posted: Apr 5, 2024
Registry last updated: Feb 18, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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Completed