Multiple Ascending Dose Study of TRN-157 in Stable Mild and Moderate Asthmatics

Inclusion criteria

Patients who meet the following criteria will be considered eligible to participate in the study:

• The patient is ≥ 18 and < 70 years of age, and gives informed consent
• Clinical diagnosis of mild to moderate asthma of at least 6 months duration and age of onset < 50 years
• Presently using ICS at moderate doses (equivalent to 200-800 µg of budesonide or 88-500 µg of fluticasone daily)
• ≥ 12% and ≥ 200 mL improvement in FEV1 to 4 puffs albuterol by metered-dose inhaler (MDI) at screening visit
• Patient is willing to use acceptable form of birth control during trial and for one month thereafter
• Ability to measure morning (AM) peak expiratory flow (PEF) on schedule using electronic peak flow meter (EPFM) and to complete the study diary correctly at least 70% of the time during the run-in period
• After 7 day withdrawal from LABA therapy and overnight withdrawal from SABA therapy (except rescue medication), patient has between 55% - 80% of predicted FEV1 at CV2

Exclusion criteria

A patient meeting any of the following criteria is not eligible for enrollment in the study:

• A clinical diagnosis of chronic obstructive pulmonary disease (COPD), chronic bronchitis, bronchiectasis, or other significant pulmonary disease other than asthma
• History of upper or lower respiratory infection within 4 weeks of screening
• History of asthma exacerbation requiring oral or systemic corticosteroids or hospital admission within 6 months of screening
• History of myocardial infarction, or cardiac conduction abnormalities, including but not limited to atrial fibrillation, and paroxysmal atrial tachycardia
• Hospitalization due to cardiac failure within the last 6 months
• History of narrow angle glaucoma or obstructive uropathy
• Current smokers or vapers, or former smokers with > 10 pack-year (self-reported) history of smoking
• Patients who presently use the following medications will not be eligible for participation:

• Long-acting muscarinic receptor antagonist (LAMA)
• LABA (but may be withdrawn and converted to SABA x 7 days prior to entry)
• Leukotriene pathway blockers
• Anti-IgE antibody (Xolair) within last 6 months prior to CV1
• Phosphodiesterase 4 (PDE4) inhibitors (e.g., Roflumilast)
• Cromolyn
• Methylxanthines (e.g., aminophylline and theophylline)
• 5-Lipoxygenase inhibitor (e.g., Zileuton)
• Allergies to LAMA therapies
• History of life-threatening asthma exacerbation requiring ICU admission, mechanical ventilation, or tracheostomy