Skip to main content
OpenTrials
Completed

NCT Number: NCT04103190

Multiparametric Imaging for Analysis of MVNT (Multinodular and Vacuolating Neuronal Tumor)

Differential diagnoses of MVNT include DNT (dysembryoplastic neuroepithelial tumor), low-grade gliomas, cortical dysplasias or even hamartomas.

Completed

Looking for future studies?

Notify Me

Key information

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Groupe Hospitalier Pellegrin, Bordeaux, France

Loading trial locations.

About this study

Differential diagnoses of MVNT include DNT (dysembryoplastic neuroepithelial tumor), low-grade gliomas, cortical dysplasias or even hamartomas.

However, in order to avoid an invasive surgical procedure to remove the lesion, a certain diagnosis of its benignity is essential. The contribution of advanced techniques in MRI, such as spectroscopy in the characterization of these lesions, has not yet been studied today

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patient over 18 years old
  • Suspicion of MVNT on an MRI: it is considered that it will be necessary at least the 2 major criteria associated with at least 1 minor criterion to enter the definition of suspicion of MVNT:

Major criteria:

  • Multinodular aspect in cluster
  • High FLAIR hypersignal / T2

Minor criteria:

  • Absence of mass effect
  • Hyposignal T1
  • Center of the lesion in hypsignal FLAIR or T1 hypersignal
  • Affiliate or beneficiary of a Social Security scheme
  • Having received informed information about the study and consenting to participate in the study

Exclusion criteria

  • Patient benefiting from a legal protection measure
  • Pregnant or lactating woman
  • Contraindication to MRI

Treatment and study plan

cerebral MRI

Device

Patients who agree to participate in the study will perform a 3T multi-parametric MRI with advanced spectroscopic imaging techniques and standard protocol.

A neurological consultation will take place during the inclusion visit as well as a questionnaire and a control MRI at 1 year and 2 years +/- 1 month.

Primary outcomes

  1. Description of a new radiological entity on Spectroscopy : the MVNT (Multinodular and Vacuolating Neuronal Tumor)

    Time frame: 1 day

    ratio of N-Acetylaspartate / Choline on Spectroscopy

  2. Description of a new radiological entity on Spectroscopy : the MVNT (Multinodular and Vacuolating Neuronal Tumor)

    Time frame: 1 day

    area under curve of the N-Acetylaspartate Spectroscopie

  3. Description of a new radiological entity on Spectroscopy : : the MVNT (Multinodular and Vacuolating Neuronal Tumor)

    Time frame: 1 day

    area under curve of choline Spectroscopie

Sponsors and collaborators

Lead sponsor

Fondation Ophtalmologique Adolphe de Rothschild

Network

Registry information

Acronym: MIAM

Important dates

Study start
2019
Primary completion
2023
Study completion
2025
First posted
Sep 25, 2019
Registry last updated
Jan 5, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.