Multimodel Exercise and Weight Loss in Older Obese Veterans With Dysmobility

Note: Study has been completed, enrollment and study interventions were severely impacted by coronavirus disease 2019 (COVID)

Older obese adults suffer disproportionately from walking mobility limitations. Sedentary, obese older adults are at an increased risk for having or developing difficulties with mobility. These individuals are often excluded from studies due to their advanced mobility limitations. A number of studies have compared the effects of weight loss alone, exercise alone, or weight loss in combination with exercise on functional performance in older adults, but none of the studies have specifically targeted subjects who use walking assistive devices. The purpose of this study is to test the effects of a 12 month multi-modal exercise rehabilitation intervention with a nutrition program versus a nutrition program only on fitness, functional performance, mobility, and muscle mass. The results of this study will lead to new and more effective interventions that could reduce disability, fall risk, injury-related hospitalization and death in older Veterans.

Inclusion criteria

• Age >= 60
• Body Mass Index (BMI) >= 30 kg/m2
• Dysmobility as define by 1 or more of the following: Use of or prescribed an assistive walking device, measured gait speed < 1.0 m/s, Four Square Step Test >/= 12 secs OR inability to complete the Four Square Step Test, and/or self-reported difficulty walking 1 km.
• Community dwelling

Exclusion criteria

• Unable to walk >0.2 mph on a treadmill for 2 minutes
• Poorly controlled hypertension >180 systolic or >100 diastolic
• Episodes of acute coronary syndrome, coronary revascularization, or major cardiac/vascular procedures within the prior 6 months
• New York Heart Association Class 3 or 4 heart failure
• Symptomatic angina at rest or during exercise
• Syncope within the past 12 months without known cause or resolution
• Chronic lung disease required oxygen dependency
• Severe spinal stenosis limiting ambulation
• Known dementia
• Mini Mental State Exam score <24
• Transtibial or above the knee amputation
• Currently enrolled and active in a supervised exercise program or Weight Management Program for Veterans (MOVE)
• Poorly controlled diabetes as defined by HbA1C >10% or frequent hypoglycemic episodes
• Currently undergoing chemotherapy and/or radiation therapy for cancer treatment