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NCT Number: NCT06924359

Multimodal Ophthalmic Imaging and Plasma Biomarkers for the Early Detection of Alzheimer's Disease

With the accelerating global aging population, dementia has become a pressing worldwide issue. This project aims to identify specific plasma biomarkers and ocular indicators for the early detection of Alzheimer's disease (AD).

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Key information

Conditions

Alzheimer's Disease (AD)

Age range

50 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Peking University First Hospital

Beijing, China

Location status: Recruiting

Location contact

Yong an Prof.Sun

CONTACT

[email protected]

83572371

Who can participate

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Male or female participants aged ≥ 50 years;
  • Participants diagnosed with Alzheimer's Disease (AD), mild cognitive decline (MCI), subjective cognitive decline (SCD), or cognitively normal (CN);
  • Signed informed consent form

Exclusion criteria

  • Presence of other neurological disorders and systemic diseases that may cause cognitive impairment;
  • Inability to cooperate with cognitive assessments;
  • Refusal to undergo blood sampling.

Treatment and study plan

Multimodal Ophthalmic Imaging and plasma biomarker

Diagnostic Test

Multimodal Ophthalmic Imaging and plasma biomarkers (Aβ42/40, p-tau181, p-tau217, NfL and GFAP）.

Primary outcomes

  1. Differences in Multimodal Ophthalmic Imaging parameter values among groups

    Time frame: Baseline

Secondary outcomes

  1. Concentration difference of plasma biomarkers (Aβ42/40, p - tau181, p - tau217, NfL and GFAP） among groups

    Time frame: Baseline

Sponsors and collaborators

Lead sponsor

Peking University First Hospital

Other

Registry information

Acronym: MOIPAD

Important dates

Study start
2025
Primary completion
2027
Study completion
2027
First posted
Apr 11, 2025
Registry last updated
Apr 11, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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