Multimodal Neuromonitoring During Normothermic Regional Perfusion for Organ Donors Determined Dead by circuLatory Criteria Following Withdrawal of Life Sustaining Measures

To determine the presence or absence of the brain circulation and function during normothermic regional perfusion assessed by intra-parenchymal neuromonitoring, non-invasive neuromonitoring and clinical examination.

Reperfusion or regain of brain function during normothermic regional perfusion will be expressed in proportion.

Restoration of either cerebral perfusion or neurological function in a patient will be considered a single brain reanimation event.

Clinical examination will consist of serial pupillary light reflex assessment and monitoring for respiratory efforts during normothermic regional perfusion.

Evidence of brain function will be determined by the presence of rhythmic delta wave activity on electroencephalography, N20 response with somatosensory evoked potentials or presence of brainstem auditory evoked potentials.

Restoration of brain circulation will be determined by the presence of cerebral blood flow (>10mls/100g/min) or brain tissue oxygen tension (>2mmHg).

To assess the feasibility of implementing multimodal neuromonitoring in DCD organ donors undergoing normothermic regional perfusion.

This will be a descriptive outcome in which investigators will calculate the duration of available data for each modality and compare it with the total observation period.

The investigators hypothesized that feasibility will be strong and that > 80% data variables will be collected for the pre-specified duration in each case.

To assess the agreement between invasive (intra-parenchymal cerebral blood flow, intra-parenchymal brain oxygenation, invasive EEG) and non invasive neuromonitoring (transcranial doppler, surface EEG, brainstem auditory evoked potentials, somatosensory evoked potentials) in determining the presence of brain circulation and function during normothermic regional perfusion