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OpenTrials
Completed

NCT Number: NCT03140917

Multimodal Assessment of Liver Volume and Function

In liver surgery peroperative assessment och the future liver remnant (FLR) is pivotal in order to avoid posthepatectomy liver failure. To date this is mainly performed by measuring the volume of the FLR. Of course FLR volume acts as a surrogate measure of FLR function and the correlation between volume and function is not always accurate. Several techniques to assess FLR function has been proposed. Hepatobiliary scintigraphy (HBS) and Dynamic MRI are the two such methods. In this study we compare HBS and MRI, in addition to contrast-enhanced CT and ICG, repeatedly performed before and after right hepatectomy in patients with colorectal liver metastases treated with neoadjuvant chemotherapy.

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Key information

Conditions

Colorectal Cancer Colonic Diseases Colorectal Neoplasms Digestive System Diseases Digestive System Neoplasms Gastrointestinal Diseases Gastrointestinal Neoplasms Intestinal Diseases Intestinal Neoplasms Liver Metastases Neoplasms Neoplasms by Site Rectal Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Karolinska University Hospital

Stockholm, Sweden

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • CRLM treated with neoadjuvant chemotherapy subjected to right hepatectomy

Exclusion criteria

-

Treatment and study plan

Multimodal liver function assessment

Diagnostic Test

HBS, MRI, CE-CT and ICG

Primary outcomes

  1. Correlation between HBS and MRI in assessment of FLR function preop

    Time frame: Preop

    HBS, MRI, CT and ICG performed the day before surgery

Secondary outcomes

  1. Correlation between HBS and MRI in assessment of FLR function POD 7

    Time frame: POD 7

    HBS, MRI, CT and ICG performed 7 days after surgery

  2. Correlation between HBS and MRI in assessment of FLR function POD 28

    Time frame: POD 28

    HBS, MRI, CT and ICG performed 28 days after surgery

Sponsors and collaborators

Lead sponsor

Karolinska University Hospital

Other

Registry information

Official study title

Multimodal Assessment of Liver Volume and Function in Patients With Colorectal Liver Metastases

Important dates

Study start
2016
Primary completion
2019
Study completion
2019
First posted
May 4, 2017
Registry last updated
Nov 26, 2019

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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