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Recruiting

NCT Number: NCT07312162

Multilevel Determinants of Socioeconomic Disparities in Geographic Late-Stage Hepatocellular Carcinoma Hotspots

This study evaluates barriers to early detection of liver cancer.

Recruiting

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Key information

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

USC / Norris Comprehensive Cancer Center

Los Angeles, California, 90033, United States

Location status: Recruiting

Location contact

Kali Zhou

CONTACT

[email protected]

949-689-9587

Kali Zhou

PRINCIPAL_INVESTIGATOR

About this study

PRIMARY OBJECTIVES:

I. To identify individual-level social and clinical determinants of socioeconomic disparities in late stage Hepatocellular Carcinoma (HCC) burden with a prospective survey of patients with incident HCC. II. To qualitatively explore the multilevel barriers to completion of the early detection pathway for HCC in low socioeconomic status (SES) populations.

OUTLINE: This is an observational study.

Participants complete surveys, have their medical records reviewed, and may complete an interview on study.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • * Adults (18+)
  • New diagnosis of HCC
  • Able to provide informed consent

Additional criteria:

  • Must complete survey
  • Residential address in a late stage hotspot
  • Medicaid insurance or uninsured
  • English, Spanish and Chinese speakers

Exclusion criteria

  • * Residence outside of Los Angeles County
  • Non-HCC liver tumors
  • Incarcerated patients
  • Pregnant women

Treatment and study plan

Non-Interventional Study

Other

Non-interventional study

Primary outcomes

  1. Social determinants of health

    Time frame: Up to 4 years

    Patient social determinants of health-related needs will be measured through a health questionnaire created for the study. The patient can respond yes or no to having a lack of transportation to and from appointments. The patient is given a scale of never true, sometimes true and often true for questions regarding food insecurity. The patient can indicate that they do or do not have housing today (or choose not to answer), and they can indicate how many times they moved in the last year as 0, 1, or 2+. For the remaining questions regarding housing, paying for utilities, paying for medications, unemployment, education and child or family care, the patient can respond yes, no or choose not to answer. Responses of yes indicate the patient has a need, and no indicates that they do not have a need.

  2. Barriers to completion of the early detection pathway for liver cancer

    Time frame: Up to 4 years

    For assessment we will conduct semi-structured interviews with key stakeholders, including low-income patients with liver cancer, providers in an interconnected safety net system, and community leaders of hotspot neighborhoods.

Study contacts

Contact information is provided by the study sponsor or research team.

Kali Zhou

CONTACT

[email protected]

323-865-0451

Sponsors and collaborators

Lead sponsor

University of Southern California

Other

Collaborators

  • National Cancer Institute (NCI)
  • National Institute on Minority Health and Health Disparities (NIMHD)

Registry information

Important dates

Study start
2022
Primary completion
2026
Study completion
2027
First posted
Dec 31, 2025
Registry last updated
Jan 30, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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