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Completed

NCT Number: NCT00708188

Multidetector Raw CT as a Single Tool in the Setting of Ischemic Stroke

This is a prospective study including acute ischemic stroke patients aged 18 to 90. Multidetector raw CT is performed in acute ischemic stroke patients. Heart, neck vessels and brain arteries are studied during the same acquisition. Results are compared with the standard methods including transesophageal echocardiography (TEE), Doppler ultrasound (DUS) and MR angiography (MRA) of neck vessels. The main criteria is the ability of CT to classify the stroke etiology correctly according to the TOAST classification in comparison with the standard methods.

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Key information

Conditions

Ischemic Stroke Brain Diseases Cardiovascular Diseases Central Nervous System Diseases Cerebrovascular Disorders Ischemia Nervous System Diseases Pathologic Processes Pathological Conditions, Signs and Symptoms Stroke Vascular Diseases

Age range

18 year–90 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Hôpital Cardiologique Louis Pradel

Bron, 69677, France

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Acute (< 1 week) ischemic stroke patient aged 18 to 90
  • Informed consent obtained
  • Presence of health insurance

Exclusion criteria

  • Pregnancy or absence of efficient contraceptive method
  • Allergy
  • Allergy to contrast material
  • Asthma
  • Renal failure (blood creatinine > 130 µmoles/l, creatinine clearance < 80 ml/mn according to Cockroft method)
  • Myeloma
  • Hyperthyroidism (uncontrolled)
  • Difficulties to synchronize CT to heart rhythm
  • Contra-indication to TEE or MRI
  • Absence or retirement of informed consent
  • Absence of health insurance

Treatment and study plan

Multidetector raw CT

Device

Multidetector raw CT

Primary outcomes

  1. Ability of CT to classify the stroke etiology correctly (TOAST classification) in comparison to reference methods (MRA, DUS, TEE)

    Time frame: classify the stroke etiology

Secondary outcomes

  1. Ability of CT to detect the source of stroke in each etiological group. Reliability of CT in quantitative measures of artery stenosis, aortic atheroma, heart thrombus, heart tumors). Tolerance of CT

    Time frame: detect the source of stroke

Sponsors and collaborators

Lead sponsor

Hospices Civils de Lyon

Other

Registry information

Official study title

Evaluation of Multidetector Raw Computerized Tomography in the Etiological Analysis of Acute Ischemic Stroke: the "COCASE" Protocol.

Acronym: COCASE

Important dates

Study start
2008
Primary completion
2013
Study completion
2013
First posted
Jul 2, 2008
Registry last updated
May 28, 2019

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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