Multicentre Prospective Cohort Study of Patients With Chronic Alcoholic and/or Metabolic Liver Disease

In 2010, the two most frequent chronic liver diseases are alcoholic and metabolic disease. The natural history of these two diseases is not well known. Indeed, most of the studies were retrospective and evaluated alcoholic disease or metabolic disease but never both diseases. However, these two diseases have the same histological lesions and can be associated. The knowledge of the natural history of these diseases could improve the management of patients in order to decrease complications and improve survival. The aim of this prospective study is to describe the natural history of chronic liver disease due to alcohol and/or metabolic syndrome and to identify factors associated with complications (ascites, encephalopathy, death, complications of obesity, diabetes or chronic alcohol abuse). All patients will be followed every 6 months for 3 years with clinical, biological and morphological parameters.

Inclusion criteria

• Age over 18 years
• chronic liver disease (liver biopsy with bridging fibrosis or cirrhosis) or non-invasive markers of fibrosis (fibrotest > 0.58, FibroScan > 7.9 kPa)
• no decompensated cirrhosis
• chronic alcohol use and/or metabolic syndrome (at least 3 criteria of metabolic syndrome)
• Written informed consent
• Patient covered by the French health insurance system

Exclusion criteria

• short term life threatening disease
• Other cirrhosis causes
• Impossibility of regular follow-up
• Under guardianship major Patient
• Presence of focal hurt suggestive of CHC
• pregnant women
• cirrhosis complication
• Child-pugh score superior or equal to 7