Multicenter Retrospective Cohort of Pulmonary NUT Carcinoma

This study is a multi-center, retrospective observational study of patients with lung NUT carcinoma. Existing clinical records from participating hospitals will be reviewed to describe patient characteristics, treatments, and outcomes. No study-related interventions will be performed. Data will be de-identified to protect patient privacy.

Active, Not Recruiting

This study is active but is not currently recruiting participants.

Key information

Conditions

NUT Carcinoma

Sex eligibility

All sexes

Study type

Observational

Primary location

Chongqing University Three Gorges Hospital

Chongqing, Chongqing Municipality, 430000, China

About this study

This is a multi-center, retrospective observational cohort study of lung NUT carcinoma. Eligible patients diagnosed with lung NUT carcinoma at participating hospitals will be identified based on pathology with supportive evidence of NUT immunohistochemistry (IHC) positivity and/or NUTM1 rearrangement/fusion. Data will be extracted from existing medical records and follow-up documentation, including demographics, tumor characteristics, staging, treatments, and outcomes. When available, routine-care pathology information and imaging data will be collected and de-identified.

Primary outcome: progression-free survival (PFS).

Secondary outcomes: overall survival (OS) and other routinely documented outcomes when available.

No new drugs, devices, procedures, or additional tests will be provided as part of this research. All data will be de-identified and stored with access controls according to applicable regulations and ethics approvals at each participating site.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Pathologically confirmed pulmonary (lung) NUT carcinoma.
Evidence of NUT immunohistochemistry (IHC) positivity and/or NUTM1 rearrangement/fusion, per local pathology report.
Diagnosed and/or treated at a participating hospital during the study period.
Availability of sufficient medical record data to abstract key baseline characteristics, treatments, and outcomes.

Exclusion criteria

Primary tumor site not in the lung.
Records insufficient to confirm the diagnosis of pulmonary NUT carcinoma.
No follow-up or outcome information available after diagnosis (insufficient for survival/outcome assessment).

Treatment and study plan

Standard-of-care anticancer treatment (retrospective)

Other

Treatments received as part of routine clinical care and recorded retrospectively in medical records, which may include surgery, radiotherapy, systemic chemotherapy, targeted therapy, and/or immunotherapy. No study-related intervention will be assigned or provided. This observational study only collects and analyzes de-identified real-world treatment and outcome data.

Primary outcomes

Progression-Free Survival (PFS)

Time frame: From diagnosis through study completion (up to May 2026)

Time from initial diagnosis (index date) to first documented disease progression per routine clinical assessment or death from any cause, whichever occurs first.

Secondary outcomes

Overall Survival (OS)

Time frame: From diagnosis through study completion (up to May 2026)

Time from initial diagnosis (index date) to death from any cause.

Sponsors and collaborators

Lead sponsor

Three Gorges Hospital of Chongqing University

Other

Registry information

Official study title

A Multicenter Retrospective Real-World Cohort Study of Pulmonary NUT Carcinoma With Integrated Clinical, Pathologic, and Imaging Analyses

Important dates

Study start: 2023
Primary completion: 2026
Study completion: 2026
First posted: Mar 9, 2026
Registry last updated: Mar 9, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Active, Not Recruiting