NCT Number: NCT03141021
First, the investigators plan to use a retrospective analysis to determine the clinical landscape of neurofibromatosis (NF)1-associated malignant peripheral nerve sheath tumor (MPNST) and precursor lesions (e.g., atypical or nodular plexiform neurofibromas). A worldwide database will be established, collecting, in a standardized manner, histologic, immunohistochemical, molecular, radiographic, treatment, and related clinical data from centers worldwide with expertise in these NF1-related cancers. Although retrospective in nature, the resulting data from this registry may reveal previously unanticipated patterns, similar to the INFACT effort outcome. This registry would then allow the acquisition of data associated with MPNST biospecimens collected under associated banks (frozen or paraffin-embedded, germline (or normal tissue DNA) samples, and any previously somatic whole-exome or whole-genome sequencing data for aggregate analyses). Second, the investigators plan to co-register patients to institutional banks in order to prospectively collect MPNST samples for analysis. These patients will be consented in order to collect the above information and for banking of tumor tissue and future studies that include genomic characterization of the tumors.
Interested in participating?
Request InfoAll sexes
Observational
Mount Sinai, Toronto, Ontario, Canada
Healthy volunteers accepted: No
Only the study team can determine whether someone qualifies for participation.
Inclusion criteria
and Exclusion Criteria:
-Any patient diagnosed with an MPNST is eligible for enrollment to this registry provided s/he consents to participate (or consent form his/her parent or legal guardian or legally authorized representative is obtained).
Time frame: 10 years
-The data collected through this registry will be used to analyze previously unanticipated patterns and prognostic clues about MPNST
Time frame: 10 years
-The data collected through this registry will be used to analyze previously unanticipated patterns and prognostic clues about MPNST
Time frame: 10 years
-The data collected through this registry will be used to analyze previously unanticipated patterns and prognostic clues about MPNST
Time frame: 10 years
-The data collected through this registry will be used to analyze previously unanticipated patterns and prognostic clues about MPNST
Time frame: 10 years
-The data collected through this registry will be used to analyze previously unanticipated patterns and prognostic clues about MPNST
Time frame: 10 years
-The data collected through this registry will be used to analyze previously unanticipated patterns and prognostic clues about MPNST
Contact information is provided by the study sponsor or research team.
Washington University School of Medicine
Other
OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.
View the official ClinicalTrials.gov record (opens in a new tab)This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.
Published trials that share one or more normalized conditions with this study.
NCT04897321
Adrenal Cortex Diseases, Adrenal Cortex Neoplasms
Memphis, Tennessee, United States
View Trial DetailsNCT05985161
Congenital, Hereditary, and Neonatal Diseases and Abnormalities, Female Urogenital Diseases
Los Angeles, California, United States
View Trial DetailsNCT06515860
Atypical Neurofibroma, Congenital, Hereditary, and Neonatal Diseases and Abnormalities
Boston, Massachusetts, United States
View Trial DetailsNCT06277154
Angiosarcoma, Desmoplastic Small Round Cell Tumor
Guangzhou, China
View Trial Details