Skip to main content
OpenTrials
Recruiting

NCT Number: NCT06280300

Multi-disciplinary Care for Brain Metastases

This is a health services intervention study aimed at understanding the impact of intensive multi-disciplinary care compared with standard care on patient-reported symptom outcomes and prognostic awareness in patients with brain metastases.

Recruiting

Interested in participating?

Request Info

Key information

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

University of Vermont Medical Center

Burlington, Vermont, 05401, United States

Location status: Recruiting

About this study

This is a cohort study of patient with newly diagnosed brain metastases assigned to standard of care (SOC) or intensive multi-disciplinary care (IMDC). Care for all patients with brain metastases involves complex medical decision making and requires input for multiple stakeholders, including medical oncology, neurosurgery, radiation oncology, and neuro-oncology. Palliative care should be an essential component of the care team for all patients with brain metastases by the very nature of this advanced malignancy. At the University of Vermont, our current process for diagnosis and management of patients with brain metastases relies heavily on the physician and team who make the initial diagnosis to consult others as they see appropriate. This process may look different for different patients. We rationalize that a systematic approach with intensive multidisciplinary care (IMDC) will benefit patients with brain metastases by providing consistent access to multi-disciplinary discussion.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patients of all genders must be at least 18 years of age.
  • Patients must have histologically confirmed, newly diagnosed brain metastases from known or suspected solid tumor primary neoplasms.
  • Patients must be able to accurately provide self-report data (e.g. per clinical judgment, cognitive function is intact).
  • Patients must be able to complete questionnaires in English.
  • Patients must have the ability to provide informed consent.

Exclusion criteria

  • Patients who are < 18 years of age are not eligible.
  • Patients who are Pregnant are not eligible.

Treatment and study plan

health services intervention

Other

Health services intervention

Primary outcomes

  1. Patient reported outcomes

    Time frame: 6-12 months

    Symptom burden based on patient reporting on Brain Mets Symptom Inventory

Secondary outcomes

  1. Feasibility

    Time frame: 6-12 months

    Number of % of patients able to complete protocol-specified activities

  2. Patient understanding of prognosis

    Time frame: 6-12 months

    Concordance with physician predication of prognosis

  3. survival

    Time frame: 6-12 months

    Survival outcomes for patients receiving best supportive care

Other outcomes

  1. Exploratory survival outcome

    Time frame: 6-12 months

    90 day and 1 year survival

Study contacts

Contact information is provided by the study sponsor or research team.

Alissa A Thomas, MD

CONTACT

[email protected]

802-847-8400

Sponsors and collaborators

Lead sponsor

University of Vermont Medical Center

Other

Registry information

Official study title

Intensive Multi-Disciplinary Care Initiative for Patients With Newly Diagnosed Brain Metastases

Important dates

Study start
2023
Primary completion
2026
Study completion
2027
First posted
Feb 28, 2024
Registry last updated
Jan 29, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.