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Recruiting

NCT Number: NCT05780957

Multi-Cancer Early Detection (MCED) of Firefighters

This study is an an observational prospective cohort research study to explore the performance of new blood and urine tests for the early detection of cancer among firefighters.

Recruiting

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Key information

Conditions

Cancer Neoplasms

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Vincere Cancer Center

Scottsdale, Arizona, 85260, United States

Location status: Recruiting

Location contact

Christine Lau, MD

CONTACT

[email protected]

(480)306-5390

Vershalee Shukla, MD

PRINCIPAL_INVESTIGATOR

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • 18 years of age or older
  • Currently employed as a firefighter, full-time or part-time
  • Taking part in Vincere's First Responder Cancer Screening Program
  • Able to donate blood and urine sample
  • Able to provide informed consent to participate in the study

Exclusion criteria

  • Deemed medically unfit for sample donation
  • Personal history of cancer in the last 5 years (with the exception of non-melanoma skin cancer)

Treatment and study plan

MCED

Other

multi-cancer early detection (MCED) test

Primary outcomes

  1. Sensitivity, specificity, positive and negative predictive performance values (PPV and NPV) to detect cancer using Elypta's MCED test, as measured in plasma, in urine, and in plasma and urine combined

    Time frame: Up to 7 years

  2. Sensitivity, specificity, positive and negative predictive performance values to detect cancer using Proteotype's MCED test, as measured in plasma.

    Time frame: Up to 2030

Study contacts

Contact information is provided by the study sponsor or research team.

Christine Lau, MD

CONTACT

[email protected]

480-306-5390

Sponsors and collaborators

Lead sponsor

Vincere Cancer Center

Other

Collaborators

  • Elypta
  • Proteotype

Registry information

Important dates

Study start
2023
Primary completion
2026
Study completion
2030
First posted
Mar 23, 2023
Registry last updated
Nov 5, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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