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NCT Number: NCT06962995

Multi-Cancer Detection Observational Cohort Study

This study assesses the incorporation of Multi-Cancer Detection (MCD) testing, designed to detect many types of cancer, into clinical practice to understand both its use and effect in real world practice conditions.

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Key information

Conditions

Cancer Neoplasms

Age range

21 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Mayo Clinic in Arizona, Scottsdale, Arizona, United States

Loading trial locations.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Has Mayo Clinic medical record number
  • Has undergone (within last 6 months) or scheduled to undergo a multi-cancer detection test (MCD) as ordered by provider
  • Able to provide informed consent
  • ≥ 21 years old
  • Ability to provide blood sample

Exclusion criteria

  • Individuals who have situations that would limit compliance with the study requirements
  • Institutionalized (i.e. Federal Medical Prison)
  • Known pregnancy (self-reported)
  • Currently undergoing active cancer treatment other than adjuvant hormone therapy
  • Invasive cancer diagnosis within the last 3 years

Treatment and study plan

Blood sample

Procedure

Up to 60 mL (about 4-5 Tbsp) of blood may be collected for an initial blood draw and up to 30 mL (about 2-3 Tbsp) may be collected for a second blood draw, 25-45 days after first blood draw. The research blood will be collected at the time of a clinical blood draw, if possible.

Other names: Biological Sample Collection, Biospecimen Collection, Specimen Collection, Blood Sample Collection

Surveys

Other

Participants will complete surveys related to attitudes and beliefs around Multi-Cancer Detection testing.

Primary outcomes

  1. Financial impact of MCD testing

    Time frame: Up to 5 years

    Assessed by types of diagnostic studies ordered as a result of positive MCD test results (e.g., to establish or rule out a cancer diagnosis).

  2. Positive actionable MCD results

    Time frame: Up to 5 years

    Assessed by the number of participants who receive positive MCD results

  3. Psychological Impact of MCD Testing

    Time frame: Baseline (after receiving MCD results)

    Assessed with the Multidimensional Impact of Cancer Risk Assessment (Adapted MICRA), which asks participants to evaluate their response to MCD test results over the past week. The MICRA consists of 20 items answered on a 4-point scale (Never, Rarely, Sometimes, Often). Higher scores generally indicate higher levels of distress or psychological impact.

  4. Change in Patient Satisfaction with MCD Test

    Time frame: Baseline; After receiving MCD results (up to 5 years)

    Participants will complete a 3-question survey, "Satisfaction with the Multi-Cancer Detection Test." Items are answered on a 5-point scale (not at all, a little, somewhat, very, extremely).

Study contacts

Contact information is provided by the study sponsor or research team.

Clinical Trials Referral Office

CONTACT

[email protected]

855-776-0015

Sponsors and collaborators

Lead sponsor

Mayo Clinic

Other

Collaborators

  • National Cancer Institute (NCI)

Registry information

Important dates

Study start
2025
Primary completion
2029
Study completion
2029
First posted
May 8, 2025
Registry last updated
Apr 6, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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