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Completed

NCT Number: NCT07132047

Mulligan SNAG Versus Active Release Technique in Cervicogenic Headache

This study is designed to compare two different manual therapy approaches for individuals with cervicogenic headaches, a type of headache that originates from the neck. Participants will be randomly assigned to one of two groups.

The first group will receive Mulligan mobilization using sustained natural apophyseal glides (SNAG) along with a home program of Mobilization self-SNAG exercises.

The second group will receive the Active Release Technique (ART) combined with a home program of stretching and strengthening exercises for the neck and shoulder muscles. Each participant will attend treatment sessions three times per week for four weeks. Pain levels, headache impact, and neck function will be evaluated at the start, after four weeks of treatment, and again at eight weeks to determine which method provides better outcomes.

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Key information

Age range

20 year–50 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

The University Of Lahore Teaching Hospital

Lahore, Pakistan

About this study

Cervicogenic headache is a form of secondary headache caused by dysfunction in the cervical spine. It is often associated with neck pain, restricted mobility, and limitations in daily activities. Manual therapy, combined with targeted exercises, is frequently used in rehabilitation to reduce pain and improve neck function. This randomized controlled trial aims to compare the effectiveness of Mulligan mobilization with sustained natural apophyseal glides (SNAG) versus the Active Release Technique (ART) in the treatment of cervicogenic headache.

Group A - Mulligan Mobilization SNAG and Home Exercise:

Participants in this group will receive the Headache SNAG technique, which involves a gentle, sustained postero-anterior glide of the second cervical vertebra for 10 to 30 seconds to help reduce headache intensity. If relief is noted, up to six repetitions may be performed. In addition, each participant will be prescribed a home program consisting of C1-C2 self-SNAG rotation using a towel to apply pressure on the posterior arch of C1 during active cervical rotation. The exercise will be completed twice daily, with 10 repetitions per session. Written instructions will be given to ensure correct performance and better compliance.

Group B - Active Release Technique and Home Exercise Program:

Participants allocated to this group will receive the Active Release Technique (ART), a hands-on treatment aimed at releasing tight muscles and improving soft tissue mobility. During ART, controlled pressure is applied to specific muscles while the neck is moved to restore normal function and reduce discomfort. Target muscles include the pectoralis major, upper trapezius, levator scapulae, rhomboids, deep neck flexors, and serratus anterior.

The intervention will also include a structured exercise program designed to stretch and strengthen the neck and shoulder muscles, reduce tension, and enhance posture. Stretches will consist of sitting chair stretch, Brugger's stretch, wall angles, and doorway stretches. Strengthening activities such as the Kibler squeeze and head/neck retractions will also be incorporated. The home program will begin with gentle neck stretches, such as tilting the head toward one shoulder and holding the position for 20-30 seconds, repeating three times on each side. Chin tucks will be performed by gently retracting the chin without tilting the head, holding for 5 seconds, and repeating 10 times for 2-3 sets. These exercises aim to relieve muscle tightness, improve alignment, and help alleviate headache symptoms.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • * Aged between 20-50 years
  • Both Male and females
  • Individuals diagnosed with neck pain accompanied by headaches.
  • Individuals with Unilateral or Bilateral cervicogenic headache.
  • Headache at least 3 times during the last 3 months.

Exclusion criteria

  • * History of inflammatory disorders (e.g Rheumatoid Arthritis).
  • History of trauma to the cervical region.
  • History of Neurological conditions (myelopathy, radiculopathy or disc problems).
  • Taking medications for headache.
  • Pregnancy.

Treatment and study plan

Mulligan Mobilization SNAG with Home Exercise

Other

This intervention combines manual mobilization and self-exercise. The therapist applies sustained postero-anterior glides to the second cervical vertebra for 10-30 seconds, up to six repetitions if pain decreases. The home program involves C1-C2 self-SNAG with a towel, maintaining end-range rotation for 10 seconds before returning to neutral. Exercises are completed twice daily for 10 repetitions each session. Participants receive illustrated instructions to promote correct execution and compliance.

Other names: Mulligan Mobilization SNAG, Self-SNAG Exercise Program

Active Release Technique with Home Exercise

Other

This approach integrates manual soft tissue release with targeted exercise. ART is applied to the neck and shoulder region, focusing on pectoralis major, upper trapezius, and levator scapulae. Exercises include wall angles, doorway stretches, Brugger's stretch, and head/neck retractions. Strengthening activities target rhomboids, deep neck flexors, and serratus anterior. The home routine consists of neck stretches, chin tucks, and postural drills, performed regularly to enhance muscle balance, posture, and headache relief.

Other names: Active Release Technique with Cervical and Shoulder Exercise Program, Soft Tissue Release and Postural Exercise

Primary outcomes

  1. Neck Disability Index (NDI) score

    Time frame: Baseline, 4 weeks, and 8 weeks after start of intervention

    The purpose of the Neck Disability Index (NDI) questionnaire is to gather data on how your neck pain has impacted your capacity to function in daily life. The NDI is divided into ten categories, each of which is rated from 0 to 5, where 5 represents "worst imaginable pain" and 0 represents "no pain". The sum of the points determines the final score, with 0 denoting no activity constraints and 50, or 100%, denoting entire activity limitations.

Secondary outcomes

  1. Numeric Pain Rating Scale (NPRS) score.

    Time frame: Baseline, 4 weeks, and 8 weeks after start of intervention

    In the segmented numerical version of the NPRS, a respondent chooses a whole number (0-10 integers) that most accurately represents the level of pain they are experiencing. A horizontal bar or line is the standard format. It takes less than a minute to finish the NPRS. Greater pain intensity is indicated by higher scores, which range from 0 to 10.

  2. Headache Disability Index (HDI) score

    Time frame: Baseline, 4 weeks, and 8 weeks after start of intervention

    The Henry Ford Hospital Headache Disability Inventory/Index (HDI) was created to measure how headaches affect day to day functioning. A 25-item headache questionnaire that was developed from the case history answers of individuals who had headaches was divided into functional and emotional subscales to evaluate how headaches and their management affected daily activities.

Sponsors and collaborators

Lead sponsor

University of Lahore

Other

Registry information

Official study title

Mulligan Mobilization Sustained Natural Apophyseal Glide Versus Active Release Technique in Cervicogenic Headache

Important dates

Study start
2025
Primary completion
2025
Study completion
2025
First posted
Aug 20, 2025
Registry last updated
Nov 18, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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