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NCT Number: NCT07675655

Mulligan Mobilization Versus PNF Technique in SIS

To investigate the differences between adding Mulligan mobilization and PNF to the conventional physical therapy program on shoulder pain, function, shoulder muscles strength, glenohumeral flexion, abduction, external rotation, and internal rotation ROM, scapular symmetry, and pectoralis minor length in patients with SIS.

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Key information

Age range

20 year–40 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Magdy Eshak

Sohag, Tahta, Egypt

Location status: Recruiting

Location contact

Marihan zakaria, Lecturer at Cairo University

CONTACT

[email protected]

01201227971

Mina Magdy Eshak, M.Sc. in Physical Therapy 2023

CONTACT

[email protected]

01277660470

Mina Magdy, M.Sc. in Physical Therapy 2023

PRINCIPAL_INVESTIGATOR

About this study

i need brief summery with same means Shoulder pain affects 4.7%-46.7% of adults annually and is the third most common musculoskeletal complaint. It accounts for 13% of sick leaves and $7 billion in healthcare costs, posing a significant economic and societal burden. SIS is the leading cause of shoulder pain and overhead reach limitation, accounting for 44-65% of cases. SIS space narrowing has two causes: intrinsic impingement (tendon degeneration from overuse, tension overload, or trauma) and extrinsic impingement (tendon inflammation from mechanical compression by an external structure).

Extrinsic factors contributing to SIS include poor posture, altered scapular or GH kinematics, posterior capsular tightness, and acromial pathology. Research demonstrates that SIS patients show restricted GH external rotation and increased humeral head translation, leading to subacromial space narrowing and tissue compression. the scapula exhibits a pattern of posterior tilting, external rotation, and upward rotation during GH elevation. Patients show altered scapular kinematics that include decreased upward rotation and increased anterior tilting and internal rotation.

rotation. The scapular muscle plays a crucial function in stabilizing the scapula, to maintain the base of the GH during motion. The upper trapezius (UT), lower trapezius (LT) and serratus anterior (SA) function as a force couple to induce scapular upward rotation, allowing the tissues beneath the coracoacromial arch to move freely. In individuals with SIS, SA activity is reduced, whereas UT and LT activity is elevated. Maintaining proper scapulohumeral rhythm is essential, particularly in the mid-range of arm elevation, to prevent subacromial impingement. The treatment approach for SIS are corticosteroid injections, nonsteroidal anti-inflammatory medications, electrotherapy treatments, manual techniques like joint mobilization, proprioceptive neuromuscular facilitation (PNF) exercises, progressive resistive exercises, taping, and stabilisation exercises. PNF is a therapeutic exercise method that enhances neuromuscular control and motor response. Adding PNF to conventional physiotherapy significantly improves pain and function compared to conventional treatment only. Also, Adding PNF to conventional program enhances early ROM gains in SIS treatment and sustain improvements post-treatment. In the manual therapy approach known as Mobilization with Movement (MWM), which was created by Brian Mulligan, the therapist applies a specially directed glide to a painful joint as the patient actively moves that same joint. The fundamental idea of MWM is to identify and correct joint positional faults caused by soft or bony tissue lesions around the joint. Four sessions of MWM significantly improve pain, pain-free shoulder flexion, maximal flexion, and external rotation in SIS patients.

To the authors' knowledge, none of the studies have investigated the differences between integrating Mulligan mobilization and PNF to the conventional physical therapy program to achieve better outcomes.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Sixty nine Males and females subjects with SIS, age between 20-40 years old and body mass index (BMI) 18-27.9 kg/m2
  • The SIS group will be limited to patients who had history of shoulder pain of >1-week duration.
  • Pain localized at the proximal anterolateral shoulder region.
  • Patients with subacromial pain syndrome with positive results of 3 of 5 tests: painful arc, pain or weakness with resisted external rotation, Neer test, Hawkins Kennedy test, and Jobe/empty can test.

Exclusion criteria

  • Patients will be excluded if they had any of the following conditions:
  • Open wounds, infection, acute injuries, swelling, rheumatoid arthritis, reflex sympathetic syndrome, or adhesive capsulitis.
  • BMI greater than 28 kg/m².
  • History of shoulder girdle fractures and dislocation, shoulder surgery in the last 12 months or full thickness rotator cuff tear.
  • History of systemic or neurological disorder, cervical radiculopathy and subjects who had received physical therapy treatment for their shoulder within the past three months.
  • History of corticosteroid injection in the shoulder region less than 12 weeks previously.

Treatment and study plan

Standard conventional program

Other

Patients receive standard conventional program inform of exercise and TENS

Proprioceptive neuromuscular facilitation (PNF) +Standard program

Other

patients receive Proprioceptive neuromuscular facilitation (PNF) +Standard conventionalprogram

MWM +Standard program

Other

patients receive MWM +Standard program

Primary outcomes

  1. The Shoulder Pain and Disability Index (SPADI)

    Time frame: at baseline and after 6 weeks post intervention

    assesses pain and disability in shoulder pathology. Patients answer five questions related to pain and eight questions related to function

  2. Shoulder ROM

    Time frame: at baseline and after 6 weeks post intervention

    the smartphone inclinometer will be used to perform clinical measurements of shoulder motion (Flexion, Abduction, External Rotation in 90- of Abduction, Internal Rotation in 90- of Abduction)

  3. The Timed Functional Arm and Shoulder Test (TFAST)

    Time frame: at baseline and after 6 weeks post-intervention

    Task 1: Hand to Head and Back (HHB) 30s Movement: Move arm from the side to touch the back of the head (palm preferred), then move down to touch the small of the back with the back of the hand.

    Scoring: 1 rep per head touch. Task 2: Wall Wash (Inward/Outward) 60s per direction Movement: Move a towel in a 12-inch diameter circle at shoulder height, touching 4 drawn marks. Start at the top mark.

    Scoring: 1 rep each time the hand passes the top mark. Done clockwise and counter-clockwise.

    Task 3: Gallon-Jug Lift - 30s Movement: Lift a 3.78 kg jug from a 36-inch high counter to lightly tap a shelf 20 inches above it, then lower it without resting.

    Scoring: 1 rep per shelf tap. Total TFAST Score Calculation To equalize all tasks for a 30-second timeframe, the final score is calculated using this formula: [HHB + (wall wash inward and outward/4) + gallon-jug lift]

Secondary outcomes

  1. Measuring isometric strength with Hand-held sphygmomanometer

    Time frame: at baseline and after 6 weeks post-intervention

    A Hand-held sphygmomanometer (HHS) will been more commonly used to measure Internal and External rotation and shoulder scaption isometric strength

  2. The Modified Lateral Scapular Slide test

    Time frame: at baseline and after 6 weeks post-intervention

    Shoulder position will be visually estimated, and the distance from the inferior angle of the scapulae and the spinous process of T7 .will be measured using a tape measure or goniometer in 3 different arm positions: neutral, 45°, and 90° The first position was with the arms by the side. The second was with the subject's hands on the hips, and the third was with the arms elevated to 90° of shoulder abduction in scaption with maximal internal rotation and

    1 kg load hold in their hands

  3. Pectoralis minor length test

    Time frame: at baseline and after 6 weeks post-intervention

    Subjects will lie supine, relaxed, with legs bent and arms at their sides in neutral rotation. An investigator will measure the vertical distance from the posterolateral acromion to the table in millimeters using a metal scale. A positive test, indicating pectoralis minor tightness, is defined as a distance greater than 2.54 cm (1 inch), while a negative test is a measurement less than or equal to 2.6 cm

Study contacts

Contact information is provided by the study sponsor or research team.

Marihan zakaria, Lecturer

CONTACT

[email protected]

01201227971

Mina Magdy, Master

CONTACT

[email protected]

01277660470 ext. 01220713396

Sponsors and collaborators

Lead sponsor

Cairo University

Other

Registry information

Official study title

Shoulder Mulligan Mobilization Versus Proprioceptive Neuromuscular Facilitation Technique In Subacromial Impingement Syndrome

Important dates

Study start
2025
Primary completion
2026
Study completion
2026
First posted
Jun 30, 2026
Registry last updated
Jun 30, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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