Mucosal and Nasal Involvement and Their Correlation With Smell and Taste Functions in Lichen Planus Patients

This study investigates smell and taste function in patients diagnosed with lichen planus, a chronic inflammatory condition affecting the skin and mucous membranes.

Adults aged 18-65 with lichen planus participated in taste and smell tests. Oral and nasal examinations were performed to check for mucosal involvement, and nasal endoscopy was used to further evaluate nasal involvement.

A healthy control group of similar age also underwent taste and smell tests to compare results with the lichen planus patients.

The study aims to better understand how lichen planus affects smell and taste, which may help improve patient care. Participation is voluntary, and all information collected will be kept confidential.

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Key information

Conditions

Lichen Planus Lichenoid Eruptions Skin Diseases Skin Diseases, Papulosquamous Skin and Connective Tissue Diseases

Age range

18 year–65 year

Sex eligibility

All sexes

Study type

Observational

Primary location

S.B.U. Istanbul Training and Research Hospital

Istanbul, 34098, Turkey (Türkiye)

About this study

The study aims to evaluate the impact of lichen planus on olfactory and gustatory functions in adults aged 18-65. Participants with lichen planus underwent taste and smell testing, oral and nasal mucosal examinations, and nasal endoscopy to detect potential mucosal involvement. A matched healthy control group also completed taste and smell tests to provide comparative data. This design allows the assessment of whether mucosal involvement in lichen planus correlates with changes in taste and smell, which may contribute to better clinical understanding and management of the disease.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Age 18-65 years Clinically diagnosed with lichen planus (patient group) Healthy individuals without lichen planus (control group) Willing and able to provide informed consent

Exclusion criteria

Nasal septum deviation Nasal polyposis, congenital olfactory dysfunction, chronic rhinosinusitis, or allergic rhinitis History of head trauma History of nasal or paranasal surgery Psychiatric or neurological disorders (e.g., Parkinson's disease, Alzheimer's disease) Persistent loss of smell following COVID-19 infection Pregnancy or breastfeeding

Treatment and study plan

Grup 1 - Lichen Planus Patients Intervention Name: Taste and Smell Testing, Oral and Nasal Examination, Nasal Endoscopy Intervention Description: Participants undergo taste and smell testing to assess

Other

Group 1 - Lichen Planus Patients:

Participants undergo taste and smell testing to assess sensory function, oral and nasal examinations to evaluate mucosal involvement, and nasal endoscopy for detailed nasal assessment.

Group 2 - Healthy Controls:

Participants undergo taste and smell testing to provide comparative data for the lichen planus group.

Primary outcomes

Smell and Taste Function

Time frame: Day 1

Participants underwent standardized smell (olfactory) and taste (gustatory) tests to assess sensory function. Tests were performed on both lichen planus patients and healthy controls to compare results and evaluate the impact of mucosal involvement on smell and taste function.

Time Frame: Single visit assessment
Smell and taste function in patients with lichen planus

Time frame: Day 1

Participants underwent standardized smell (olfactory) and taste (gustatory) tests to assess sensory function. Tests were performed on both lichen planus patients and healthy controls to compare results and evaluate the impact of mucosal involvement on smell and taste function.

Sponsors and collaborators

Lead sponsor

Istanbul Training and Research Hospital

Other Gov

Registry information

Official study title

Correlation of Mucosal and Nasal Involvement With Smell and Taste Functions in Patients With Lichen Planus

Acronym: LP-NOSE

Important dates

Study start: 2026
Primary completion: 2026
Study completion: 2026
First posted: May 6, 2026
Registry last updated: May 6, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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Completed