Mucoadhesive Film With/without Acmella Oleracea & Triamcinolone Acetonide for Aphthous Ulcers

Participants who consent and meet the inclusion criteria will be allocated into 3 groups using block randomization: group 1: mucoadhesive film with Acmella oleracea extract, group 2: 0.1% triamcinolone acetonide, and group 3: mucoadhesive film without Acmella oleracea extract.

Inclusion criteria

• Healthy participants aged 18-50 years without any underlying diseases.
• Participants are voluntary and have signed the informed consent.
• Participants are literate.
• Participants can follow the treatment guidelines and follow up.
• Participants have one untreated oral ulcer lesion.

• An ulcer has occurred within 48 hours.
• The ulcer size is less than 10 mm.
• The ulcer is clearly visible and located on non-keratinized oral mucosa such as buccal mucosa, labial mucosa, alveolar mucosa, or buccal vestibule.
• The ulcer must be painful.
• If an ulcer is caused by a denture or orthodontic appliance, the cause must be eliminated before participation.
• Participants must not be currently participating in any other clinical studies about oral ulcer

Exclusion criteria

• Participants with allergies to herbal extracts, Acmella oleracea, or steroids.
• Participants with chronic underlying diseases.
• Participants with underlying diseases that may affect wound healing.
• Participants receiving anti-analgesic drug, systemic steroids, antibiotics, hormones, NSAIDS, or any drugs that affect the oral mucosa.
• Oral ulcer lesion larger than 10 mm or lesions resembling herpetic form of aphthous ulcers.
• Oral ulcers are caused by infection or associated with systemic diseases.
• Participants with poor oral hygiene requiring emergency treatment.
• Participants who smoke or consume alcohol regularly.
• Participants who are pregnant, breastfeeding, or planning to become pregnant during the study period.