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Completed

NCT Number: NCT01009658

MSG and Gastrointestinal Motility

The purpose of this study is to clarify the physiological function of sodium glutamate by measuring its effect on upper GI motility ( gastric emptying).

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Key information

Conditions

Gastroesophageal Reflux Deglutition Disorders Digestive System Diseases Esophageal Diseases Esophageal Motility Disorders Gastrointestinal Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Gunma university hospital

Maebashi, Gunma, 3718511, Japan

About this study

Amino acids such as monosodium glutamate are known to stimulate both endocrine and exocrine secretion. In addition, there is a report that oral intake of glutamate evokes the activation of vagal afferent nerves in the rat. Thus, such amino acids are thought to be influential in the process of digestion and absorption.

. To investigate the effect of monosodium glutamate on gastrointestinal motility, we planned a single-blind randomized study. The participants will take either monosodium glutamate or sodium chloride before the first examination of upper GI motility and the other agent before the second examination. The order of intake will be randomized by the envelope method.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Healthy subjects
  • Must not have digestive symptoms
  • Must not eat within six hours of study participation

Exclusion criteria

  • Regular medications for the gastrointestinal tract
  • Previous Helicobacter pylori infection
  • Previous abdominal surgery

Treatment and study plan

Monosodium Glutamate

Dietary Supplement

Oral intake of 2.0 g of monosodium glutamate on the examination day and 0.6 g of sodium chloride on the other examination day.

Sodium chloride

Dietary Supplement

Oral intake of 0.6 g of sodium chloride on the examination day and 2.0 g of monosodium glutamate on the other examination day.

Primary outcomes

  1. Gastric emptying

    Time frame: 0-5 hours

    half emptying time

Sponsors and collaborators

Lead sponsor

Gunma University

Other

Registry information

Official study title

Effect of Monosodium Glutamate on Upper Gastrointestinal Tract Motility

Important dates

Study start
2009
Primary completion
2015
First posted
Nov 9, 2009
Registry last updated
Mar 26, 2015

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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