MRI Results in Dupuytren's Contracture Before and After Injection With Xiaflex

Collagenase injections for the treatment of Dupuytren's Contracture is a newly approved protocol which has shown early efficacy. There are very few studies which examine the MRI appearance of Dupuytren's disease. There are no studies that evaluate the condition of the cord after collagenase injection.

Inclusion criteria

• Subject has a diagnosis of Dupuytren's Disease affecting only the metacarpophalangeal joint of the 4th or 5th finger.
• Subject has only one finger affected by the disease.
• Patients will be 35 years of age of older.
• Patients will be able to read, speak, and understand English or have available adequate translation assistance and be able to provide voluntary written consent to participate.

Exclusion criteria

• Female patients who are nursing or pregnant, or plan to become pregnant during the treatment phase.
• Patient has a chronic muscular, neurological or neuromuscular disorder that affects the hands.
• Patient has known allergy to collagenase or any other excipient of Xiaflex.
• Patient has received any collagenase treatments before the first dose of Xiaflex.
• Patient with abnormal coagulation, including patients who have received anticoagulant medications other than low-dose aspirin within 7 days of the injection.