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OpenTrials
Completed

NCT Number: NCT02694406

MRI Perfusion in Adnexal Masses

As ovarian cancer is characterized by an anarchic neovascularization resulting in a wide number of immature microvessels. These vessels are characterized by a lack of coverage by pericytes and the higher expression of one of the receptors of Vascular Endothelial Growth Factor on both endothelial and epithelial cells of ovarian cystadenocarcinomas. These physio pathogenic characteristics have been demonstrated to be in line with variations of MR perfusion parameters.

Unlike many lesions that occur in other parts of the body, biopsy should not be performed in adnexal masses that demonstrate no evidence of peritoneal disease because it may cause spillage of cystic contents, potentially leading to iatrogenic up-staging of what may have been a malignant tumor that was limited.

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Key information

Conditions

Complex Adnexal Masses Disease Pathologic Processes Pathological Conditions, Signs and Symptoms

Sex eligibility

Female

Study type

Observational

Primary location

Ahmed Abbas, Assiut, Cairo Governorate, Egypt

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Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • complex adnexal mass
  • patient fit for surgery

Exclusion criteria

  • any general contraindication to MRI
  • severely ill patients
  • those with claustrophobia.

Treatment and study plan

MRI perfusion

Device

contrast-enhanced MR imaging including perfusion weighted imaging (PWI)

Primary outcomes

  1. detect the number of malignant adnexal masses

    Time frame: 2 weeks

Sponsors and collaborators

Lead sponsor

Assiut University

Other

Registry information

Official study title

Added Value of MRI Perfusion in Evaluation of Complex Adnexal Masses

Acronym: MRI-CAM

Important dates

Study start
2015
Primary completion
2017
Study completion
2017
First posted
Feb 29, 2016
Registry last updated
Jun 27, 2018

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

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This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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