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NCT Number: NCT05194254

MRI-Eye Tracking Pairing, a Tool for Assessing Social Cognition in Children With ASD

Most studies use static visual percepts that are less representative of joint attention versus an ecological environment. This has the consequence of decreasing the perception of an interaction with a social partner, which is an essential step in achieving joint attention. The originality of this study is to improve the design of visual percepts (in the form of video) in order to mimic an ecological environment as much as possible by using MRI-ET coupling. The second originality of this study is the longitudinal exploration of the neurodevelopment of social cognition in autistic children. Studies by the Redcay and Oberwelland teams observe different activations at different ages. The hypothesis is that the perception of joint attention varies over time in people with ASD. To date, there are no studies to determine the influence of childhood neurodevelopment in autistic people on the perception of joint attention. It would be unprecedented to use the MRI-ET pairing as a tool for assessing social cognition as a function of the development of children with ASD.

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Key information

Age range

10 year–20 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

CHU Amiens Picardie

Amiens, Picardie, 80054, France

Location status: Recruiting

Location contact

Jean-Marc CONSTANS, PhD

CONTACT

[email protected]

+33322087511

Luc Vandromme, Pr

SUB_INVESTIGATOR

Olivier Balédent, PHD

SUB_INVESTIGATOR

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

For the group of people with Autism Spectrum Disorders (experimental group):

  • Age between 10 to 20 years old
  • Diagnosis of ASD (CARS) ≥ 30 performed at inclusion
  • IQ test evaluation (regardless of the result) performed by a trained psychologist
  • Obtaining informed oral and written consent after appropriate information
  • Obtaining informed oral and written consent from the legal guardian after information
  • Be affiliated with social security
  • No contraindication to magnetic resonance imaging

For the TD (Typical Development) group of people (control group):

  • Age between 10 to 20 years old
  • Diagnosis of ASD (CARS) <30 performed at inclusion
  • IQ test evaluation (regardless of the result) performed by a trained psychologist
  • Obtaining informed oral and written consent after appropriate information
  • Obtaining informed oral and written consent from the legal guardian after information
  • Be affiliated with social security
  • No contraindication to magnetic resonance imaging

Exclusion criteria

For all groups:

  • Age outside the range 10 to 20 years
  • Person with a contraindication to MRI (including claustrophobia, pace maker, neurosurgical clips, vascular clips, heart valves, ventriculoperitoneal valves, cochlear implant, neurostimulator, intraocular metal shards, joint prosthesis, etc.)
  • Person suffering from major obesity (> 140 kg) not allowing him to enter the tunnel of the MRI machine (diameter <70cm)
  • Pregnant or breastfeeding woman
  • Person under guardianship or guardianship or deprived of liberty by a judicial or administrative decision

For TD people (control group):

  • Person with psychiatric disorders such as attention disorder with or without hyperactivity, depression, bipolar disorder and schizophrenia.
  • Person with a neurological history such as epilepsy and / or neurovascular accident.

Treatment and study plan

MRI-ET

Other

coupled fMRI and Eye Tracking tools

Primary outcomes

  1. difference of mapping IRM-ET results between both patient groups

    Time frame: one day

    both patient groups are : the group of people with Autism Spectrum Disorders and Typical Development group of people

Study contacts

Contact information is provided by the study sponsor or research team.

Jean-Marc Constans, Pr

CONTACT

[email protected]

03 22 08 75 15

Sponsors and collaborators

Lead sponsor

Centre Hospitalier Universitaire, Amiens

Other

Registry information

Acronym: IRM-ET

Important dates

Study start
2022
Primary completion
2025
Study completion
2025
First posted
Jan 18, 2022
Registry last updated
May 28, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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