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NCT Number: NCT02170155

MRI-changes in Morphometry and Cerebro Spinale Fluid (CSF) Flow in Spinal Cord Disorders

Understanding the onset and progression of spinal cord disorders is an important aim in clinical neurology. An early diagnosis with consequent therapy might prevent the progression of disability. Therefore, we aim to determine structural and dynamic changes in the microstructure of the spinal cord and CSF, and to explore the relationships between the MRI parameters, clinical disability, and electrophysiology.

In some patients that undergo decompressive surgery CSF pressure will be measured invasive perioperative for 24h to find out if functional limitations and structural changes correlate with the spinal pressure and the spinal perfusion when the spinal cord is damaged.

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Key information

Conditions

Spinal Injury Back Injuries Spinal Injuries Wounds and Injuries

Age range

18 year–80 year

Sex eligibility

All sexes

Study type

Observational

Primary location

University of Zurich, Balgrist University Hospital

Zurich, Canton of Zurich, 8008, Switzerland

Location status: Recruiting

Location contact

Armin Curt, MD

CONTACT

[email protected]

+41 44 386 39 01

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Cervical injury
  • Informed consent
  • Age 18-80
  • CSM

Exclusion criteria

  • No other neurologic disorder and psychiatric disorder
  • Seizure
  • MRI incompatibility
  • Pregnancy

Treatment and study plan

Primary outcomes

  1. Morphometric changes and changes in cerebro spinal fluid (CSF) flow and spinal cord movement in patients and control subjects will be correlated to functional deficits and neurophysiological data (regression model analysis).

    Time frame: Each patient will undergo a MRI scan, clinical and electrophysiological examinations at baseline, after 6 months and after 1, 2, 3, 4, and 5 years. Controls will undergo 1 MRI scan and some scan of retest analysis

  2. Assessment of CSF pressure dynamics in the perioperative setting

    Time frame: Perioperative for 24hours

Study contacts

Contact information is provided by the study sponsor or research team.

Patrick Freund, PhD

CONTACT

[email protected]

Sponsors and collaborators

Lead sponsor

University of Zurich

Other

Collaborators

  • Balgrist Foundation
  • Foundation Wings For Life

Registry information

Important dates

Study start
2012
Primary completion
2026
Study completion
2026
First posted
Jun 23, 2014
Registry last updated
Dec 22, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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