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NCT Number: NCT07602686

MRI and Local Anesthesia

The purpose of this research is to investigate the utility of using dental-dedicated MRI as a measurement tool to observe and evaluate the administration of local anesthesia in dental patients.

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Key information

Conditions

Dental Anesthesia

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

University of Minnesota

Minneapolis, Minnesota, 55455, United States

Location contact

Rachel Uppgaard, DDS, FACS

CONTACT

[email protected]

612-209-9176

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Adult age 18 or older
  • Health status of American Society of Anesthesiologists (ASA) class 1 or 2
  • Able to provide informed consent
  • Able to appear in person at OMRIC on the days indicated for the study

Exclusion criteria

  • ASA class 3 or higher
  • Pregnant patients
  • Taking any medication that would affect pain perception or interact with local anesthetic
  • Allergic/history of adverse reaction to local anesthetic or any component in the local anesthetic
  • Paresthesia in the area of innervation of Cranial Nerve V3
  • Active infection or abscess in the oral and maxillofacial region
  • History of temporomandibular disorder, maximum incisal opening less than 15mm
  • History of recent dental trauma (within the past 6 months)
  • Dental hypersensitivity
  • Claustrophobia and/or conditions of anxiety or motion disorder (for MRI purposes)
  • Metallic, electronic, or magnetic implants or devices classified as MR Unsafe or Conditional by the American College of Radiology
  • Unable to give informed consent

Treatment and study plan

ddMRI

Device

Dental MRI imaging

Primary outcomes

  1. Patient reported sensation - 5min

    Time frame: 5 minutes after the nerve block

    Minimum value: No numbness Maximum value: Numb High scores mean a successful outcome for the block.

  2. Patient reported sensation - 1 hour

    Time frame: within 1 hour of the nerve block

    Minimum value: No numbness Maximum value: Numb High scores mean a successful outcome for the block.

  3. Ability to sense light touch

    Time frame: within 1 hour of the nerve block

    binary scale. Options are yes or no

  4. Ability to sense pressure

    Time frame: within 1 hour of the nerve block

    Minimum value: 1.65 Maximum value: 6.65 Low scores mean that the participant can sense more, and that the block was less effective

  5. Ability to sense direction of touch (only if can sense VonFrey fibers)

    Time frame: within 1 hour of the nerve block

    Patient reports direction of sensation (up/down/right/left). This is scored 5 times per site

  6. Ability to distinguish sharp versus dull (only if can sense VonFrey fibers)

    Time frame: within 1 hour of the nerve block

    Patient reports sharp versus dull sensation. This is scored 5 times per site

Study contacts

Contact information is provided by the study sponsor or research team.

Rachel Uppgaard, DDS, FACS

CONTACT

[email protected]

612-209-9176

Sponsors and collaborators

Lead sponsor

University of Minnesota

Other

Registry information

Official study title

MRI Evaluation of Local Anesthesia Administration

Acronym: MRI and LA

Important dates

Study start
2026
Primary completion
2029
Study completion
2029
First posted
May 22, 2026
Registry last updated
Jul 21, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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