MRI Analysis and Degenerative Spine

Analysis of MRI advanced techniques in degenerative spinal disease.

The main questions it aims to answer are:

* Can we assess microstructural integrity of compressed nerve roots in degenerative spinal disease * What are the image biomarkers affected by disease * How they evolve with disease progression and treatment

Recruiting

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Key information

Conditions

Spine Disease Bone Diseases Musculoskeletal Diseases Spinal Diseases

Age range

50 year–85 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Hospital da Luz Setúbal

Setúbal, 2900-722, Portugal

Location status: Recruiting

Location contact

Nuno Cristino, MD

CONTACT

[email protected]

+351919484946

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Age between 50 and 85 years
Diagnosis of spinal disease by clinical and imagiological criteria
More than 3 months duration of disease
Ability to give consent
Fluent portuguese speaker

Exclusion criteria

Previous spine surgery
Spinal instability
Neurological disease that might interfere with walking
Known orthopedic conditions that causes significant gait impairment
Dementia or development disorder with cognitive impairment
Inability to give consent

Treatment and study plan

MRI advanced techniques

Diagnostic Test

Participants will be submitted to MRI studies at diagnosis, during disease evolution and after treatment. Data collected will be analysed by two different neuroradiologists using advanced techniques.

Primary outcomes

ODI - Oswestry Disability Index

Time frame: 18 months

Measured using the ODI scale (range 0 - 50)
Lumbar Pain Intensity

Time frame: 18 months

Measured using the Numeric Pain Rating Scale (range: 0 - 10 )

Study contacts

Contact information is provided by the study sponsor or research team.

Nuno A.R. Cristino, M.D.

CONTACT

[email protected]

+351919484946

Sponsors and collaborators

Lead sponsor

Universidade Nova de Lisboa

Other

Registry information

Important dates

Study start: 2024
Primary completion: 2024
Study completion: 2026
First posted: Dec 8, 2023
Registry last updated: Jan 30, 2024

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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Recruiting