USARIEM
Natick, Massachusetts, 01760, United States
NCT Number: NCT02423551
The objective of this study is to determine the impact of consuming MREs as the sole source of subsistence for 21 days on gut bacteria community composition and gut health. Up to 80 free-living adults will be randomized to consume their usual diet or only MREs for 21 consecutive days. MREs will be provided by the Military Nutrition Division, US Army Research Institute of Environmental Medicine (USARIEM). Fecal, urine and blood samples will be collected periodically before, during and after the intervention to measure gut barrier integrity, gut bacteria community composition, and markers of gut health, inflammation, and nutritional status.
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Notify Me18 year–62 year
All sexes
Interventional
Not applicable
Natick, Massachusetts, 01760, United States
Healthy volunteers accepted: Yes
Only the study team can determine whether someone qualifies for participation.
Inclusion criteria
Exclusion criteria
MRE consumption
Time frame: Baseline to 10 days, 21 days and 31 days
Urine excretion of saccharide probes; circulating zonulin, intestinal fatty acid binding protein, claudin-3, lipopolysaccharide and GLP2 concentrations
Time frame: Baseline to 10 days, 21 days and 31 days
16S rRNA gene sequencing
Time frame: Baseline to 10 days, 21 days and 31 days
Serum C-reactive protein
Time frame: Baseline to 10 days, 21 days and 31 days
Serum TNF-alpha
Time frame: Baseline to 10 days, 21 days and 31 days
Serum IL-6
Time frame: Baseline to 10 days, 21 days and 31 days
Plasma LPS
Time frame: Baseline to 10 days, 21 days and 31 days
Blood ferritin, soluble transferrin receptor, hemoglobin, hematocrit
Time frame: Baseline to 10 days, 21 days and 31 days
Blood 25-hydroxyvitamin D, 1,25-dihydroxyvitamin D, parathyroid hormone
Time frame: Baseline to 10 days, 21 days and 31 days
Blood folate, vitamin B12, homocysteine
Time frame: Baseline to 10 days, 21 days and 31 days
Blood prealbumin
Time frame: Baseline to 10 days, 21 days and 31 days
Urine calcium
Time frame: Baseline to 10 days, 21 days and 31 days
Blood zinc, zinc receptor expression
United States Army Research Institute of Environmental Medicine
Fed
Effects of Meal, Ready-to-Eat (MRE) Consumption on Gut Health
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View the official ClinicalTrials.gov record (opens in a new tab)This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.
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