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NCT Number: NCT03582189

MR Guidance for Liver and Pancreas

This is a single centre, single arm, prospective feasibility study that aims to see whether magnetic resonance imaging (MRI) as a source of image guidance before each radiation treatment fraction is feasible, and also if it may provide information that could potentially be used during the treatment to improve the radiation treatment plan.

Patients will have 5 MRIs with each of their RT sessions. If patients' RT treatment will consist of more than 5 fractions, only 5 MRIs will be done with any 5 RT fractions. Patients will be completing a short questionnaire at the end of each MRI. A patient questionnaire will also be completed at the end of the study to assess for patient satisfaction.

There will be 30 evaluable patients enrolled to the study.

Recruiting

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Key information

Conditions

Magnetic Resonance Imaging Digestive System Diseases Digestive System Neoplasms Endocrine Gland Neoplasms Endocrine System Diseases Liver Diseases Liver Neoplasms Neoplasms Neoplasms by Site Pancreatic Diseases Pancreatic Neoplasms

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

University Health Network - Princess Margaret Cancer Centre

Toronto, Ontario, M5G 2M9, Canada

Location status: Recruiting

Location contact

Laura Dawson, MD

CONTACT

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patients 18 years or older
  • Diagnosed with locally advanced pancreatic cancer or hepatocellular carcinoma being considered for treatment with chemoradiation, long course RT, or SBRT with curative intent or palliative intent, planned for 5 or more RT fractions

Exclusion criteria

  • Contraindications for MRI: ferromagnetic prosthesis, pacemaker / implanted defibrillator, claustrophobia

Treatment and study plan

MRI

Other

Patients who consent to this study will have an abdominal MRI prior to or immediately after each fraction of radiation treatment in the case of those patients that are undergoing SBRT or those receiving palliative treatment. On patients receiving definitive chemoradiation, an abdominal MRI will be performed prior to or immediately after radiation treatment once per week during the any five weeks of treatment

Primary outcomes

  1. Patient Satisfaction Survey

    Time frame: At study completion (day5 or week 5, depending on type of treatment)

    To evaluate patient satisfaction with the MR guidance process, a modified version of a questionnaire previously used at our institution will be performed at the end of the study

  2. MRI-Anxiety Questionnaire

    Time frame: Prior to or before MR session 1 (day 1 or week 1, depending on type of treatment)

    This instrument will be used to evaluate patient related anxiety after each MR

  3. MRI-Anxiety Questionnaire

    Time frame: Prior to or before MR session 2 (day 2 or week 2, depending on type of treatment)

    This instrument will be used to evaluate patient related anxiety after each MR

  4. MRI-Anxiety Questionnaire

    Time frame: Prior to or before MR session 3 (day 3 or week 3, depending on type of treatment)

    This instrument will be used to evaluate patient related anxiety after each MR

  5. MRI-Anxiety Questionnaire

    Time frame: Prior to or before MR session 4 (day 4 or week 4, depending on type of treatment)

    This instrument will be used to evaluate patient related anxiety after each MR

  6. MRI-Anxiety Questionnaire

    Time frame: Prior to or before MR session 5 (day 5 or week 5, depending on type of treatment)

    his instrument will be used to evaluate patient related anxiety after each MR

Study contacts

Contact information is provided by the study sponsor or research team.

Edel Sexton

CONTACT

[email protected]

416-946-4501 ext. 5576

Jana Huang

CONTACT

[email protected]

Sponsors and collaborators

Lead sponsor

University Health Network, Toronto

Other

Registry information

Official study title

A Feasibility Study of Magnetic Resonance Imaging (MRI) as a Platform for Image Guidance and Adaptive Radiation Therapy in Patients With Liver or Pancreatic Cancer

Important dates

Study start
2018
Primary completion
2027
Study completion
2027
First posted
Jul 10, 2018
Registry last updated
Mar 5, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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