Skip to main content
OpenTrials
Not Yet Recruiting

NCT Number: NCT06876870

MR-Evaluation of Renal Function in Anesthetized Pediatric Patients

The goal of this study is to investigate the effect of the anesthetic agents sevoflurane or propofol on the blood flow and oxygen delivery to the kidneys.

Pediatric patients who are planned to undergo an MRI scan with generalized anesthesia will be randomized to either IV anesthesia with propofol or inhalation anesthesia with sevoflurane. Both of these anesthetic methods are commonly used for anesthesia on an everyday basis.

In addition to the clinically indicated MRI, Multiparametric MRI will be performed to visualize the effect of the anesthetic agent on renal blood flow, perfusion and oxygenation.

Not Yet Recruiting

Trial opening soon.

Get Notified

Key information

Conditions

Renal Blood Flow Anesthesia MRI Renal Oxygenation

Age range

1 month–14 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Phase 4

About this study

See the study protocol

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Pediatric Patients (1 month -14 years of age)
  • Indicated for MRI with anesthesia
  • ASA (American Society of Anesthesiologists) physical status I-III

Exclusion criteria

  • Known renal impairment or chronic kidney disease
  • Severe cardiac or pulmonary disease
  • Allergy to either Propofol or Sevoflurane
  • Contraindications to Magnetic Resonance Imaging
  • Contraindications to either Propofol or Sevoflurane
  • Declined participation or declined consent from patients, parents or guardians
  • Ongoing acute kidney injury

Treatment and study plan

Anesthesia Maintenance Agent

Drug

Difference in renal blood flow (RBF) between Propofol and Sevoflurane groups. Quantified by specific Multiparametric MRI metrics (e.g., (Renal blood flow by phase contrast imaging) (regional perfusion by Arterial Spin labeling (ASL) and global and regional oxygenation by Blood oxygen dependent signal (BOLD))

Other names: Anesthesia, Sevoflurane, Propofol

Primary outcomes

  1. Differences in RBF, as measured by phase contrast imaging with mpMRI, between propofol and sevoflurane anesthesia.

    Time frame: The extra imaging is expected to take 20-30 minutes.

    Multiparametric MRI via phase contrast imaging to quantify renal blood flow, will be standardized to renal area. By quantifying renal blood flow we will be able to evaluate the effects of propofol and sevoflurane on RBF.

Secondary outcomes

  1. Differences in regional renal tissue perfusion, as measured by arterial spin labelling (ASL) with mpMRI, between propofol and sevoflurane anaesthesia

    Time frame: The whole MpMRI will take around 20-30 minutes all together where the primary and secondary outcomes can later be extracted via analysis of the images

    To investigate the effect of Propofol and Sevoflurane on regional tissue perfusion in the renal cortex and medulla.

  2. Differences in regional and global renal oxygenation, as measured by Blood Oxygen Level Dependent (BOLD) signal via mpMRI, between propofol and sevoflurane anaesthesia.

    Time frame: The whole MpMRI will take around 20-30 minutes all together where the primary and secondary outcomes can later be extracted via analysis of the images

    To explore potential differences related to the Sevoflurane or Propofol on regional and global renal oxygenation.

  3. The difference in relation of RBF to systemic non-invasive blood pressure, between propofol and sevoflurane anaesthesia

    Time frame: The entire MpMRI will take around 20-30 minutes all together where the primary and secondary outcomes can later be extracted via analysis of the images

    To investigate how RBF varies in relation to systemic blood pressure in paediatric patients in generalized anaesthesia with propofol or Sevoflurane.

  4. The difference plasma renin concentration, measured by a blood sample, between propofol and sevoflurane anaesthesia

    Time frame: 1 minute

    To explore the effect of Sevoflurane and Propofol on serum Renin concentration as a surrogate marker for Renal sympathetic nerve activation.

Study contacts

Contact information is provided by the study sponsor or research team.

Arash Emami, PhD student

CONTACT

[email protected]

+46763222722

Robert Frithiof, Professor

CONTACT

[email protected]

Sponsors and collaborators

Lead sponsor

Uppsala University

Other

Collaborators

  • Uppsala University Hospital

Registry information

Acronym: MERAPED

Important dates

Study start
2025
Primary completion
2026
Study completion
2027
First posted
Mar 14, 2025
Registry last updated
Mar 25, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Related clinical trials

Published trials that share one or more normalized conditions with this study.