Brigham and Women's Hospital
Boston, Massachusetts, 02115, United States
Location contact
Laura Rigolo
CONTACT
Yanmei Tie, PhD
CONTACT
Yanmei Tie, PhD
PRINCIPAL_INVESTIGATOR
NCT Number: NCT07650994
This research will compare a new type of functional MRI (fMRI) called naturalistic viewing (also called movie watching) to standard clinical fMRI techniques. Standard clinical fMRI currently uses multiple tasks such as reading and responding to words or sentences to determine which areas of the brain are responsible for language. Surgeons can use this information to help plan brain surgeries. This research will help determine if the movie-watching fMRI is equivalent or better than the standard task-based fMRI. If so, it could be useful for planning patients' surgeries in the future, without the need for multiple tasks.
Trial opening soon.
Get Notified21 year–70 year
All sexes
Interventional
Not applicable
Boston, Massachusetts, 02115, United States
Laura Rigolo
CONTACT
Yanmei Tie, PhD
CONTACT
Yanmei Tie, PhD
PRINCIPAL_INVESTIGATOR
Healthy volunteers accepted: No
Only the study team can determine whether someone qualifies for participation.
Inclusion criteria
Exclusion criteria
Functional magnetic resonance imaging (fMRI) is a type of non-invasive imaging that measures blood oxygen level-dependent (BOLD) signal changes in the brain when a task is performed (such as reading) or BOLD signal changes during resting or watching naturalistic stimuli (such as movie clips).
Other names: fMRI
Neuropsychological assessments are standardized tests used to evaluate cognitive, behavioral, and emotional functions that reflect the performance of different brain systems. These tests can be on paper or on a computer.
Time frame: From enrollment to up to 6 months after brain surgery.
Sensitivity and specificity based on the proportion of activation within and outside of language regions-of-interest (ROIs).
Time frame: From enrollment to up to 6 months after brain surgery.
Laterality index (LI) based on proportion of activation in the left vs. right hemisphere in language regions-of-interest (ROIs).
Time frame: From enrollment to up to 6 months after brain surgery.
Concordance with language fiber tracts identified by diffusion MRI in terms of the Euclidean distance between fMRI language activations and the tracts.
Time frame: From enrollment to up to 6 months after brain surgery.
Sensitivity and specificity computed relative to ECS positive/negative areas.
Contact information is provided by the study sponsor or research team.
Laura Rigolo
CONTACT
Yanmei Tie, PhD
CONTACT
Brigham and Women's Hospital
Other
Naturalistic Neuroimaging for Neurosurgical Brain Mapping
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View the official ClinicalTrials.gov record (opens in a new tab)This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.
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