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NCT Number: NCT06829433

Movement Dynamics of Knee Osteoarthritis and Total Knee Replacement

This research aims to explore differences in walking and functional movement mechanics, exercise response, and physical activity between people with osteoarthritis (OA), those who have undergone total joint replacement, and healthy individuals.

Recruiting

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Key information

Age range

40 year–85 year

Sex eligibility

All sexes

Study type

Observational

Primary location

School of Psychology, Health and Sport Sciences, University of Portsmouth

Portsmouth, Hampshire, PO1 2ER, United Kingdom

Location status: Recruiting

Location contact

Josie Morris, BSc

PRINCIPAL_INVESTIGATOR

Josie Morris, Bsc

CONTACT

[email protected]

02392 846395

About this study

People living with OA tend to be less physically active than those without the disease, which is often due to pain, stiffness and joint instability. This reduction in physical activity can lead to additional health problems down the line. When the disease becomes severe, joint replacement surgeries are sometimes performed to relieve pain and improve individuals' quality of life. However, despite reducing pain, there is little evidence to show that joint replacement surgeries encourage individuals to return to healthy physical activity levels.

Reasons for the lack of change may include a failure to address unhealthy walking and movement patterns which could still be causing pain and instability and reduced physical fitness levels.

By investigating these reasons, we hope that findings from this study will help to inform future interventions that improve clinical outcomes and quality of life for individuals with OA and post-joint replacement.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Diagnosed symptomatic bilateral or unilateral knee osteoarthritis, self-reported ability to walk without an aid for 10 minutes and to ascend and descend stairs, no neurological conditions or other musculoskeletal pathology/injury which would impact walking gait.

Exclusion criteria

  • Unable to walk at 0.8 m/s, exclusion based on IMO screening, non-English speaking, lacking ability to consent.

Treatment and study plan

No intervention

Other

Observational cross-sectional study

Primary outcomes

  1. Peak knee adduction moment

    Time frame: From the start of a biomechanical movement testing visit to the end (approximately 2 hours)

    The external knee adduction moment (KAM), which reflects medial-to-lateral knee joint load distribution during gait, has become an OA treatment target. The peak KAM is a strong predictor of presence, severity, and the rate of progression of knee OA.

Study contacts

Contact information is provided by the study sponsor or research team.

Joseph Moore, PhD

CONTACT

[email protected]

Josie Morris, BSc

CONTACT

[email protected]

02392 846395

Sponsors and collaborators

Lead sponsor

University of Portsmouth

Other

Registry information

Official study title

Quantifying the Movement Dynamics of Adults Living With Total Knee Arthroplasty and Knee Osteoarthritis

Acronym: MDOA&TKR

Important dates

Study start
2024
Primary completion
2026
Study completion
2026
First posted
Feb 17, 2025
Registry last updated
Feb 21, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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