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Completed

NCT Number: NCT07220200

MOVE Protocol - Movement-Oriented Velocity of Engagement

A Prospective, Multi-Site, Interventional Case-Series Evaluating the MOVE (Movement-Oriented Velocity of Engagement) Protocol for Musculoskeletal Pain Recovery

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Key information

Age range

18 year–70 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Indian Institute of Kinesiology & Biomechanics Science (IIKBS), Burhānpur, Madhya Pradesh, India

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About this study

The MOVE Protocol is a structured, biomechanics-based rehabilitation framework designed to accelerate recovery from musculoskeletal pain conditions through progressive mobilization and neuromuscular control. This interventional case-series involved multiple clinical and training centers (BodyGNTX, GFFI, IIKBS, ASFU) and applied standardized MOVE sessions under the supervision of certified movement specialists. Assessments included pain scoring (NRS), functional mobility (LEFS/UEFI), and balance control, measured at baseline, week 2, week 4, and week 8. The protocol followed ICH-GCP E6(R2) and Helsinki 2013 guidelines, with institutional ethics approval from MMSx Authority IREB. The study demonstrated safe and effective early-movement outcomes across diverse populations, emphasizing mobility, load optimization, and neuromuscular revalidation.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • • Adults aged 18-65 years diagnosed with acute or subacute musculoskeletal pain or movement restriction (≤12 weeks duration).
  • Capable of performing supervised rehabilitation and daily movement tasks.
  • Able to provide informed consent and comply with study assessments.
  • Baseline pain score ≥4 on the Numerical Rating Scale (NRS).

Exclusion criteria

  • Chronic pain (>12 weeks) or neurological disorders affecting movement control.
  • Post-surgical cases or fractures within the past 3 months.
  • Cardiopulmonary or systemic illness contraindicating exercise participation.
  • Pregnancy or conditions limiting safe participation in physical rehabilitation.
  • Refusal to sign informed consent.

Treatment and study plan

MOVE Rehabilitation Protocol

Behavioral

The MOVE (Movement-Oriented Velocity of Engagement) protocol is a biomechanics-based rehabilitation approach targeting early mobilization and functional recovery for musculoskeletal pain conditions. The structured program includes four key phases: Mobilize, Optimize Load, Validate Neural Control, and Energize Recovery, applied over 8 weeks under therapist supervision.

Primary outcomes

  1. Pain Reduction (NRS Score)

    Time frame: Baseline, Week 2, Week 4, and Week 8

    Change in Numeric Rating Scale (NRS) for pain intensity from baseline to week 8 following the MOVE (Movement-Oriented Velocity of Engagement) rehabilitation program. Participants rated pain on a 0-10 scale where 0 = no pain and 10 = worst possible pain.

Secondary outcomes

  1. Functional Improvement (LEFS / UEFI Score)

    Time frame: Baseline, Week 2, Week 4, Week 8

    Change in Lower Extremity Functional Scale (LEFS) or Upper Extremity Functional Index (UEFI) from baseline to week 8, reflecting mobility and activity performance improvement post-MOVE intervention.

  2. Balance and Postural Stability (Timed Single-Leg Stance Test)

    Time frame: Baseline, Week 4, Week 8

    Improvement in single-leg stance duration and balance control across sessions as measured by standardized postural tests.

  3. Participant Perceived Recovery (Global Rating of Change Scale)

    Time frame: Week 8

    Participants rate overall improvement on a 7-point Global Rating of Change (GROC) scale at week 8 to capture subjective recovery perception.

Sponsors and collaborators

Lead sponsor

MMSx Authority Institute for Movement Mechanics and Biomechanics Research Inc

Unknown

Registry information

Official study title

A Prospective, Multi-Site, Interventional Case-Series Evaluating the MOVE (Movement-Oriented Velocity of Engagement) Protocol for Musculoskeletal Pain Recovery

Important dates

Study start
2024
Primary completion
2024
Study completion
2025
First posted
Oct 23, 2025
Registry last updated
Oct 23, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

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This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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