Mouthwash With Chlorhexidine 0.12%/Ethyl Alcohol 7% Compared to Ethyl Alcohol 7%

Clinical triple-blind randomized controlled trial.

With two arms to the study:

• Mouth rinses with chlorhexidine-based solution at a concentration of 0.12%, using as a vehicle to 7% ethyl alcohol.
• Mouthwashes with solution based only 7% ethyl alcohol.

GOAL. Assess whether there decrease in the rate of oral colonization by gram-negative bacteria in patients with chemotherapy by using chlorhexidine mouthwash.

SPECIFIC OBJECTIVES:

• The rate of the oral colonization by gram-negative bacteria initiation of chemotherapy.
• The rate of oral colonization by gram-negative bacteria after 10 days of initiation of chemotherapy.
• Identify microbiologically gram-negative bacteria colonizing the oral cavity.

SECONDARY OBJECTIVES

• The presence of severe neutropenia and fever in each study group during the first 10 days of starting treatment

Inclusion criteria

• Patients over 18years, no upper age limit.
• Acceptance of participation in the study.
• Signature of informed consent.
• Inpatient and remain hospitalized for at least 10 days.
• The following haematological diagnosis:

• acute lymphoblastic leukemia.
• acute myelogenous leukemia.
• relapsed non-Hodgkin lymphoma.
• Receiving Chemotherapy scheme as a treatment for the underlying disease

Exclusion criteria

• Patients who choose not to participate in the study.
• Patients in whom no possible mouthwashes.
• Patients who willingly choose to withdraw from the study.
• Patients who develop conditions in which the administration is not possible rinses.
• Duration of hospital stay less than 10 days, regardless of cause.