Mouse Allergen and Asthma Intervention Trial

The MAAIT is a randomized, controlled trial of a home intervention to reduce mouse allergen exposure in mouse allergic children with asthma and mouse allergen exposure. Participants will be randomized to either the Integrated Pest Management (IPM) Group or the Education Group. The IPM Group will receive professional mouse abatement, education, two HEPA filters, allergen-proof mattress and pillow encasements, and targeted cleaning. The Education Group will receive education about IPM at the beginning of the trial and then after completion of the trial, will receive the IPM intervention. Participants will be followed for 12 months.

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Key information

Conditions

Asthma Bronchial Diseases Hypersensitivity Hypersensitivity, Immediate Immune System Diseases Lung Diseases Lung Diseases, Obstructive Mouse Allergen Exposure Mouse Allergy Respiratory Hypersensitivity Respiratory Tract Diseases

Age range

6 year–17 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Phase 3

Primary location

Johns Hopkins, Baltimore, Maryland, United States

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

persistent asthma
exacerbation, previous 12 months
evidence of mouse sensitization
high levels of mouse allergen in home
ages 5-17 years

Exclusion criteria

intermittent asthma
no exacerbation in previous 12 months
not sensitized to mouse
low or undetectable mouse allergen in home
other lung disease aside from asthma

Treatment and study plan

integrated pest management

Other

The IPM intervention will include professional mouse abatement, two HEPA filters, targeted cleaning, education about IPM, and allergen-proof mattress and pillow encasements. The intervention will be delivered at baseline to the IPM Group, and then repeated if recurrent or persistent mouse infestation is present.

Education

Other

This group will receive education about mouse IPM.

Primary outcomes

change in asthma symptoms

Time frame: 0, 3, 6, 9, 12 months

days of asthma symptoms

Sponsors and collaborators

Lead sponsor

Johns Hopkins University

Other

Collaborators

Boston Children's Hospital
Columbia University

Registry information

Acronym: MAAIT

Important dates

Study start: 2010
Primary completion: 2016
Study completion: 2016
First posted: Dec 1, 2010
Registry last updated: Mar 16, 2017

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

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