Motor Slowing and Its Lesion-related Correlates in Alzheimer's Disease

Inclusion criteria

• Patients

• Age between 40 and 85
• French mother tongue
• Consulting at the Amiens Memory Resource and Research Centre (CMRR) for:
• MCI, according to Albert et al.'s criteria (Albert et al., 2011)
• Mild dementia (MMSE>20) due to AD, according to McKhann's criteria (McKhann et al., 2011).
• Mild dementia due to LBD, according to McKeith et al.'s criteria (McKeith et al., 2005).
• Mild dementia due to FTLD, according to Rascovsky et al.'s criteria (Rascovsky et al., 2011).
• Social security coverage
• Healthy controls

• Healthy age and gender matched volunteers will be recruited into the study from the general population.

Exclusion criteria

• Reading or writing difficulties related to a learning disorder or illiteracy.
• A medical history with a potentially significant impact on cognition (non-corrected thyroid disorders or heart failure):

• NYHA stage IV dyspnoea.
• respiratory impairment requiring oxygen therapy.
• liver impairment.
• kidney failure, progressing neoplastic disease, or past or present alcohol abuse.
• Past or present neurological disorders other than those having prompted consultation in the Memory Clinic:

• stroke.
• meningitis or encephalitis.
• severe head injury.
• sensorimotor impairments (sensory, proprioceptive, cerebellar and visual impairments).
• epilepsy (requiring ongoing treatment),
• psychiatric disorders (other than treated depression).
• treatment with psychotropic medications (other than anxiolytics or antidepressant withdrawn or initiated in the previous month). Patients with parkinsonian syndrome were examined in the "on-drug" state.
• Impossibility to perform a neuropsychological evaluation or brain MRI.
• Withdrawal from the study at any time, if desired.
• Pregnancy
• Contra-indication to MRI:

• nerve stimulators
• cochlear implants
• ferromagnetic foreign bodies close to nervous structures in the eye or brain
• cerebral shunts
• dental appliances
• Legal guardianship or incarceration.