Hôpital Henry Gabrielle - Médecine physique et Réadaptation, Hospices Civils de Lyon, 20 Route de Vourles,
Saint-Genis-Laval, 69230, France
Completed
NCT Number: NCT02860403
Motor Imagery for Reach-to-grasp Rehabilitation After Tetraplegia
Single center, pilot study, to evaluate the influence of Motor Imagery (MI) on functional rehabilitation and cerebral plasticity through the qualitative and quantitative mental practice approach. For this, the investigators will use magnetoencephalography (MEG) but also physiological and behavioral indicators developed by the Laboratoire de la Performance Motrice, Mentale et du Matériel (P3M) of Université Claude Bernard Lyon 1 and its partners.
Completed
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Notify MeKey information
Conditions
Age range
18 year–55 year
Sex eligibility
All sexes
Study type
Interventional
Phase
Not applicable
Primary location
Who can participate
Healthy volunteers accepted: Yes
Only the study team can determine whether someone qualifies for participation.
Inclusion criteria
- 18-55 years old,
- quadriplegia elicited by spinal cord injury (SCI) at the C5, C5-C6, C6, or C6-C7 level,
- complete infra-lesional motor deficit according to the ASIA impairment scale with finger and forearm flexor muscles paralysis,
- post-traumatic period >6 months (since a motor recovery plateau is usually reached at 6-month post-SCI
Exclusion criteria
- non-stabilized hypertension or pathological autonomic nervous system dysfunction (e.g., orthostatic hypotension),
- cerebral damage and/or cognitive deficit,
- elbow or shoulder joint amplitude restriction, upper limb para-osteoarthropathy,
- participation to another study
- presence of metallic objects within the body incompatible with MEG or functional magnetic resonance imaging (fMRI) recordings.
Treatment and study plan
motor imagery
ProcedureIntervention consisted of supervised MI during which the participants were trained to imagine performing a single-joint wrist extension movement and a multiple-joint reach-to-grasp movement using tenodesis. The two movements were practiced in separate blocks and each 45 minute MI session consisted of six to eight blocks. Within a given block patients; i) performed the movement once, ii) imagined it using visual imagery (between five and ten repetitions), iii) performed the movement again, and iv) imagined it using kinesthetic imagery (between five and ten repetitions). All movements (performed and imagined) were timed by the experimenter to ensure that the durations of both imagined and physically practiced movements were similar. Imagery vividness was controlled with self-rated assessments using a visual analogic scale (from 0, the image or feeling was absent, to 10 when it was as clear or intense as physical practice).
Primary outcomes
-
Motor imagery ability
Time frame: 10 weeks
Motor imagery ability assessed by magnetoencephalography measurements
Secondary outcomes
-
Movement time (MT)
Time frame: 10 weeks
Kinematic parameters of movement: temporal parameters: movement time (MT)
-
absolute time to peak velocity
Time frame: 10 weeks
Kinematic parameters of movement: temporal parameters: absolute time to peak velocity
-
movement amplitude at peak velocity
Time frame: 10 weeks
Kinematic parameters of movement: temporal parameters: movement amplitude at peak velocity
-
time to opening
Time frame: 10 weeks
Kinematic parameters of movement: temporal parameters: time to opening
-
time to maximal opening
Time frame: 10 weeks
Kinematic parameters of movement: temporal parameters: time to maximal opening
-
amplitude of maximal opening
Time frame: 10 weeks
Kinematic parameters of movement: temporal parameters: amplitude of maximal opening
-
Trajectory of movement measured in the XY plane
Time frame: 10 weeks
Kinematic parameters of movement: spatial parameters: Trajectory of movement measured in the XY plane
-
height of elbow and wrist at the moment of grasping an object, measured in mm in the YZ plane
Time frame: 10 weeks
Kinematic parameters of movement: spatial parameters: height of elbow and wrist at the moment of grasping an object, measured in mm in the YZ plane
-
muscular force evaluated by muscle testing performed by a physiotherapist
Time frame: 10 weeks
muscular force evaluated by muscle testing performed by a physiotherapist (score from 0 to 5)
-
joint amplitude evaluated in degrees (°) by the physiotherapist
Time frame: 10 weeks
-
Box and Block test
Time frame: 10 weeks
Box and Block test performed by an occupational therapist
-
Minnesota test.
Time frame: 10 weeks
Minnesota test performed by an occupational therapist
-
amplitude of electrodermal responses
Time frame: 10 weeks
mental chronometric assessment associated with acquisition of electrodermal responses
-
duration of electrodermal responses
Time frame: 10 weeks
mental chronometric assessment associated with acquisition of electrodermal responses
-
Kinesthetic and Visual Imagery Questionnaire
Time frame: 10 weeks
The Kinesthetic and Visual Imagery Questionnaire (KVIQ) will allow a qualitative evaluation of the mental representation capacity of patients
Sponsors and collaborators
Lead sponsor
Hospices Civils de Lyon
Other
Registry information
Important dates
- Study start
- 2013
- Primary completion
- 2013
- Study completion
- 2013
- First posted
- Aug 9, 2016
- Registry last updated
- May 28, 2019
OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.
View the official ClinicalTrials.gov record (opens in a new tab)This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.