Motor Adaptation to Split-Belt Treadmill in Parkinson's Disease

In this proposal, the investigators will investigate whether adapting gait to modulations imposed by a split-belt treadmill, improves walking ability and reduces FOG. The investigators will test the hypothesis that motor adaptation deficits underlie FOG and that these problems are modifiable with training. To address these suppositions, the investigators propose a multi-centric study conducted in two research labs with expertise in split-belt gait analysis and FOG: University of Leuven (KUL) and Christian-Albrechts-University Kiel (CAUK). As freezers have been shown to have more difficulty with consolidation of motor learning, the investigators aim in study I (pilot phase) to first understand which split-belt parameters are optimal for training gait flexibility and lead to consolidated gains in daily walking. For this study, the investigators will recruit 60 freezers and 60 healthy controls, pooled across centers, and manipulate different split-belt conditions in one learning and retention session.

Inclusion criteria

• Diagnosis of Parkinson's Disease as per the UK Parkinson's Disease Society Brain Bank Criteria
• Classification as a Freezer with the New Freezing of Gait Questionnaire (score > 0)
• Ability to walk at least 5 min. without any aid
• Stable anti-parkinsonian medication at least 1 month prior to participation

Exclusion criteria

• Neurologic diseases other than PD
• Orthopedic injuries that could influence gait and balance
• Participation in treadmill training more than once a week
• Cognitive impairment (MMSE<24) or inability to follow test instructions
• Self-reported DBS-related postural or gait disturbances
• Cardiovascular risk factors
• Peripheral neuropathy