Motivational Behavioral and Functional MRI Impairment in Patients With Chronic Neuropathic Pain

The main hypothesis of this study is that the alteration of the reward circuitry underlying the motivational deficit in chronic pain patients compared to healthy subjects results in a decrease in the capacity for reward learning. The fMRI studies have shown that this type of learning depends on the dopaminergic system innervating key regions of the reward system.

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Key information

Conditions

Chronic Pain Neurologic Manifestations Pain Pathological Conditions, Signs and Symptoms Signs and Symptoms

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Hôpital Fondation Adolphe de Rothschild

Paris, France

Location status: Recruiting

Location contact

Amélie YAVCHITZ

CONTACT

[email protected]

+3314836454

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

For cases: patients managed in the neurosurgery department or at CETD for chronic neuropathic pain, of central or peripheral origin.
For controls: matched to a case on age (±5 years) and sex

Exclusion criteria

Neurodegenerative or inflammatory neurological pathology
Clinical depressive syndrome
High doses of opioid treatment (greater than 100 mg/day of morphine equivalent)
Impaired judgment or inability to receive information that does not allow the performance of behavioral tasks
Absolute contraindication to MRI (e.g. pacemaker, implantable pacemaker, metallic intra-orbital foreign body)

Treatment and study plan

reward learning task

Other

during usual follow-up patients will complete a remard learning task questionnaire. This questionnaire cannot be assimilated to a clinical intervention.

Primary outcomes

To compare reward learning ability in patients with chronic neuropathic pain compared with an age (±5 years) and gender-matched control population

Time frame: Day 0

the reward learning ability will be assessed using a specific task. The result of the task questionnaire is a numeric score.

Sponsors and collaborators

Lead sponsor

Fondation Ophtalmologique Adolphe de Rothschild

Network

Registry information

Acronym: MOTION

Important dates

Study start: 2023
Primary completion: 2027
Study completion: 2027
First posted: Jan 27, 2023
Registry last updated: Jan 5, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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