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Completed

NCT Number: NCT02302521

Motion Immune Magnetic Resonance Imaging (MRI)

The purpose of this study is to evaluate our recently developed MRI reconstruction strategy for producing artifact-free neuro and abdominal MRI data. The new reconstruction strategies, including 1) REKAM and 2) MUSE, are capable of effectively removing motion-related artifacts resulting from global and local motion during neuro and free-breathing abdominal MRI scans, without modifying the MRI pulse sequences and protocols that are currently used in clinical scans. The study team aims to recruit 60 subjects across multiple challenge patient populations: 10 healthy young adults (age 20-30) and 10 healthy older adults (aged 50-70) for abdominal MRI, as well as 20 tremor dominant PD patients and 20 children (age 4-8) for brain MRI scans. There are no known risks in taking MRIs and a unique code will be assigned to each participant to protect their PHI.

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Key information

Conditions

Parkinson's Disease Basal Ganglia Diseases Brain Diseases Central Nervous System Diseases Movement Disorders Nervous System Diseases Neurodegenerative Diseases Parkinson Disease Parkinsonian Disorders Synucleinopathies

Sex eligibility

All sexes

Study type

Observational

Primary location

Duke University Medical Center

Durham, North Carolina, 27710, United States

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • subject's age is within one of the following age ranges (4-8, 20-30, or 50-70 years old);
  • male or female;
  • healthy volunteer or diagnosed with PD ; and
  • devoid of the following exclusion criteria.

Exclusion criteria

  • claustrophobia or other MRI contraindications (including pregnancy);
  • diagnosis for dementia (Alzheimer's, Lewy Body, or Vascular);
  • symptomatic psychotic disorders;
  • depression with psychotic symptoms;
  • other psychotic or schizophrenic disorders;
  • recent neuroleptic treatment;
  • history of cardiovascular disease;
  • history of stroke or Transient Ischemic Attack;
  • cancer (other than skin cancer) within the last three years;
  • hospitalization for neurological/psychiatric condition;
  • significant handicaps (e.g., visual or hearing loss, mental retardation) that would interfere with neuropsychological testing or the ability to follow study procedures; or
  • any other factor that in the investigators' judgment may affect patient safety or compliance.

Treatment and study plan

Multiplex Sensitivity Encoding (MUSE)

Device

It is an algorithm for MRI post-processing/image reconstruction (see reference: Chen).

Primary outcomes

  1. Rating of image quality (based on 8 criteria) by multiple radiologists (blind to reconstruction method)

    Time frame: 1 day (At time of image analysis)

    The ratings will be compared to compare the quality of images processed with MUSE versus conventional reconstruction methods

Sponsors and collaborators

Lead sponsor

Duke University

Other

Registry information

Official study title

Examining the Clinical Utility of Motion Immune MRI Across Multiple Patient Populations

Important dates

Study start
2015
Primary completion
2016
Study completion
2016
First posted
Nov 27, 2014
Registry last updated
Aug 11, 2017

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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