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Completed

NCT Number: NCT01129752

Mothers With a History of Depression and Their 10-14 Year Old Daughters

The purpose of this study is to investigate risk factors associated with depression and how such factors might be transmitted cross-generationally. The investigators are conducting an integrative assessment of emotion regulation and stress reactivity in a group of mothers with and without a history of depression and their daughters.

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Key information

Age range

9 year–15 year

Sex eligibility

Female

Study type

Observational

Primary location

Stanford University Department of Psychology, Stanford, California, United States

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About this study

The purpose of this study is to investigate risk factors associated with depression and how such factors might be transmitted cross-generationally. We are conducting an integrative assessment of emotion regulation and stress reactivity in a group of mothers with and without a history of depression and their daughters. We use a range of methodologies to evaluate these processes, including self-report measures, information-processing performance, HPA-axis functioning and reactivity, and neural responses to emotional stimuli following exposure to stressful experiences.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Eligible mothers must read and speak English fluently and have a child between the ages of 9 and 15 years old.
  • Mothers must either have no history of psychopathology or have a history of depression during their child's lifetime.

Exclusion criteria

  • Eligible mothers cannot:
  • currently be in treatment for drug or alcohol abuse
  • have significant symptomatology related to psychopathology outside of depression
  • have a medical history of neurological injury or impairment.
  • Mothers who meet the requirements for inclusion in the control group must not have a history of any Axis I disorder.

Treatment and study plan

No intervention

Other

there is no intervention for this study

Primary outcomes

  1. Onset of depression

    Time frame: 18 months

    participants are interviewed in an 18-month follow-up session

Sponsors and collaborators

Lead sponsor

Stanford University

Other

Collaborators

  • National Institute of Mental Health (NIMH)

Registry information

Official study title

The Neural Correlates of Mood and Cognitive Bias in a Population at Risk for Depression: Maternal Cognitive and Emotional Functioning

Important dates

Study start
2004
Primary completion
2011
Study completion
2011
First posted
May 25, 2010
Registry last updated
Jun 23, 2011

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

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This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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