Mothers Living With HIV and Their Adolescent Children

* Context: Mothers living with HIV (MLH) and their children face predictable challenges: maintaining physical and mental health, parenting while ill, and addressing HIV-related stressors. * Objective: To evaluate the efficacy of a family-based intervention over time; to contrast the life adjustments of HIV-affected families and their non-HIV-affected neighbors in the current treatment era. * Design: Randomized controlled trial of MLH and a longitudinal comparison of MLH to a neighborhood cohort using random effect regression. * Participants and Intervention: MLH (n = 339) and their school-age children (n = 259) were randomly assigned to receive 1) an intervention of 16 sessions in a cognitive-behavioral, small-group format; or 2) control. MLH and their children were compared to non-HIV-affected families recruited at shopping markets. Participant retention was high: 84% at 6 months, 83% at 12 months, and 78% at 18 months. * Main Outcome Measures: Family functioning and conflict, mental and physical health, sexual behavior, and substance use.

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Key information

Conditions

Family Relations Behavior Blood-Borne Infections Chemically-Induced Disorders Communicable Diseases Genital Diseases HIV Infections Immune System Diseases Immunologic Deficiency Syndromes Infections Lentivirus Infections Mental Disorders Mental Health Personal Satisfaction Physical Health Psychological Well-Being RNA Virus Infections Retroviridae Infections Risky Sexual Behavior Sexually Transmitted Diseases Sexually Transmitted Diseases, Viral Substance Use Substance-Related Disorders Urogenital Diseases Virus Diseases

Age range

18 year and older

Sex eligibility

Female

Study type

Interventional

Phase

Not applicable

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

for Intervention/Control, mother living with HIV:

Mother or primary female caregiver
Enrolled in HIV-related clinical cares
At least one child between the age of 6 and 20 years

Inclusion criteria

for neighborhood control, non-HIV-affected mother:

Mother or primary female caregiver
not HIV-positive
At least one child between the age of 6 and 20 years

Exclusion criteria

(Intervention/Control/Neighborhood):

Mother less than 18 years old
Unable or willing to give informed consent
Psychosis or neurological damage as judged by the investigator in consultation with clinical supervisor

Treatment and study plan

Cognitive-behavioral, small-group format sessions

Behavioral

The intervention was delivered in either English- or Spanish-speaking groups of 5 to 8 mothers living with HIV twice weekly for 1.5 to 2 hours each over eight weeks (n = 16 sessions).

Sponsors and collaborators

Lead sponsor

University of California, Los Angeles

Other

Collaborators

National Institute of Mental Health (NIMH)

Registry information

Acronym: TALK LA

Important dates

Study start: 2005
Primary completion: 2008
Study completion: 2008
First posted: Oct 2, 2009
Registry last updated: Nov 28, 2016

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed