Fuzhou Eye Hospital
Fuzhou, Fujian, 350007, China
Enrolling by Invitation
NCT Number: NCT07549711
Morphological-Gene-Clinical Phenotype Correlation Study of the Long Anterior Zonule
Long anterior zonules (LAZ) is an anatomical anomaly of the anterior segment in which zonular fibers extend abnormally forward onto the anterior lens capsule. It is potentially associated with glaucoma, late-onset retinal degeneration, and increased risks during cataract surgery. This study introduces a 3D visualization system to enhance the detection rate of LAZ. By integrating multiple imaging modalities, it systematically assesses the morphological characteristics of LAZ, aiming to provide an evidence-based foundation for subsequent efforts to establish diagnostic consensus, optimize preoperative assessments for glaucoma and cataract surgery. By elucidating the genetic mechanisms and genotype-phenotype correlations of LAZ, this research can provide theoretical support for the early identification of high-risk populations, genetic consultation, and personalized treatment.
Enrolling by Invitation
Interested in participating?
Request InfoKey information
Conditions
Age range
18 year and older
Sex eligibility
All sexes
Study type
Observational
Primary location
Who can participate
Healthy volunteers accepted: Yes
Only the study team can determine whether someone qualifies for participation.
Inclusion criteria
- Control Group Routine cataract patient, no signs of LAZ, intraocular pressure ≤21 mmHg, and no history of glaucoma, pigment dispersion syndrome, or other eye diseases that clearly affect the anterior segment structure.
- LAZ Group Patients with cataracts combined with LAZ were independently evaluated by at least two senior ophthalmologists under slit-lamp examination or a 3D visualization system, and were required to meet the predefined diagnostic criteria for LAZ.
- LAZ Pedigree Cohort First-degree and above relatives of the LAZ proband, aged ≥18 years, regardless of the presence or absence of LAZ or related ocular disease phenotypes.
Exclusion criteria
- Secondary glaucoma with a clear etiology (such as inflammatory, traumatic, or neovascular glaucoma, etc.)
- History of previous intraocular surgery (e.g., cataract, glaucoma, or vitreoretinal surgery), with refractive surgery history documented but analyzed with caution
- Presence of ocular conditions affecting anterior segment imaging quality, such as corneal leukoma or severe cataract
- Individuals with severe systemic diseases (e.g., poorly controlled diabetes, connective tissue diseases) or mental disorders that hinder cooperation during examinations
- Pregnant or lactating women.
Treatment and study plan
Control
GeneticRoutine cataract patient, no signs of LAZ, intraocular pressure ≤21 mmHg, and no history of glaucoma, pigment dispersion syndrome, or other eye diseases that clearly affect the anterior segment structure.
Long anterior zonules
GeneticPatients with cataracts combined with LAZ were independently evaluated by at least two senior ophthalmologists under slit-lamp examination or a 3D visualization system, and were required to meet the predefined diagnostic criteria for LAZ.
LAZ Pedigree
GeneticFirst-degree and above relatives of the LAZ proband, aged ≥18 years, regardless of the presence or absence of LAZ or related ocular disease phenotypes.
Primary outcomes
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Axial length
Time frame: 1 day pre-op
Axial length, anterior chamber depth, lens thickness, corneal curvature, corneal diameter
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Anterior chamber depth
Time frame: 1 day pre-op
-
Lens thickness
Time frame: 1 day pre-op
-
Corneal curvature
Time frame: 1 day pre-op
-
Corneal diameter (WTW)
Time frame: 1 day pre-op
-
Imaging of LAZ morphology and distribution
Time frame: 1 day pre-op
The images and videos about slit lamp and 3D visualization system.
-
Gene sequencing
Time frame: through study completion, an average of 1 year
Identification of pathogenic genes
Secondary outcomes
-
Uncorrected Visual Acuity (UCVA)
Time frame: 1 day pre-op; 1 day post-op; 7 days post-op; 30 days post-op
-
Corrected Distance Visual Acuity (CDVA)
Time frame: 1 day pre-op; 1 day post-op; 7 days post-op; 30 days post-op
-
Spherical equivalent (SE)
Time frame: 1 day pre-op; 1 day post-op; 7 days post-op; 30 days post-op
-
Intraocular pressure
Time frame: 1 day pre-op; 1 day post-op; 7 days post-op; 30 days post-op
-
Intraoperative complications
Time frame: Intraoperative
Intraoperative capsular complications occur
-
Age
Time frame: 1 day pre-op
-
Sex
Time frame: 1 day pre-op
-
Diagnosis
Time frame: 1 day pre-op
Diagnosis of accompanying ocular and systemic conditions, such as glaucoma, macular degeneration, hypertension, diabetes, etc.
-
Anterior chamber volume (ACV)
Time frame: 1 day pre-op
-
Anterior chamber area (ACA)
Time frame: 1 day pre-op
-
Angle opening distance (AOD)
Time frame: 1 day pre-op
-
Trabecular iris angle (TIA)
Time frame: 1 day pre-op
-
Images of the ciliary body structure
Time frame: 1 day pre-op
Images of the ciliary body captured by UBM
Sponsors and collaborators
Lead sponsor
Fuzhou Eye Hospital
Other
Registry information
Official study title
A Morphological, Genetic, and Clinical Phenotype Association Study of the Long Anterior Zonule (LAZ) Based on Multimodal Imaging and Genetic Testing
Important dates
- Study start
- 2025
- Primary completion
- 2028
- Study completion
- 2028
- First posted
- Apr 24, 2026
- Registry last updated
- Apr 24, 2026
OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.
View the official ClinicalTrials.gov record (opens in a new tab)This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.