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OpenTrials
Completed

NCT Number: NCT03790358

Mood Effects of Serotonin Agonists

The purpose of this study is to determine the effects of very low doses of serotonergic agonists on depressed mood in human volunteers.

Completed

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Key information

Conditions

Healthy

Age range

18 year–35 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Phase 1

Primary location

Matthew Bona, Chicago, Illinois, United States

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Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • English fluency
  • High school level education
  • BMI between 19 and 30

Exclusion criteria

  • Diagnosed medical condition
  • women who are nursing, pregnant, or plan to become pregnant within 3 months
  • History of psychotic disorder or family history of psychotic disorder

Treatment and study plan

Lysergic Acid Diethylamide

Drug

Drug will be administered in solution form.

Primary outcomes

  1. Change From Baseline in Profile of Mood States (POMS)

    Time frame: End of study (Baseline - time 0 and approximately 8 weeks later)

    The POMS measures individuals' mood states. This is a validated scale to measure positive and negative mood states. The POMS contains 30 items and assesses six identified mood factors: Tension-Anxiety, Depression-Ejection, Anger- Hostility, Vigor-Activity, Fatigue-Inertia, and Confusion-Bewilderment. Scoring of the instrument provides a global score of 0 to 120 or individual domain scores. Lower scores indicate better mood state. The POMS brief form is a simple self-rating instrument.

Sponsors and collaborators

Lead sponsor

University of Chicago

Other

Registry information

Important dates

Study start
2018
Primary completion
2023
Study completion
2023
First posted
Dec 31, 2018
Registry last updated
Jan 24, 2024

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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