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Completed

NCT Number: NCT01825070

Montmorency Cherry Juice and Uric Acid Metabolism

Cherries have been show to possess the ability to reduce uric acid concentrations and inflammation. Tart Montmorency cherries possess a higher concentration of the plant compounds than other cherries and hence makes the expectation possible that Montmorency cherries will lower uric acid and inflammation.

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Key information

Conditions

Inflammation Pathologic Processes Pathological Conditions, Signs and Symptoms

Age range

18 year–40 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Northumbria University

Newcastle upon Tyne, Tyne and Wear, NE1 8ST, United Kingdom

About this study

Plasma and urinary uric acid concentration, plasma phytochemical content and inflammatory biomarkers will be measured in order to elucidate the effects of an acute dose of tart cherry juice on indices related to the condition of gout.

Participants will be required to attend the laboratory at a range of time points over two periods of 96 hours, separated by a 7 day washout period, to provide blood samples. In order to provide a baseline sample, participants will attend the laboratory in the morning following an overnight fast and voiding of any urine. Following this participants will be given 30mls (30 mls provides 323 mg/380 µmol of anthocyanins) of tart cherry juice or placebo, diluted with 60 mls of water to consume within 10 minutes. Participants will be required to consume identical dosages of the supplement immediately prior to evening meals and breakfasts (or same time each morning following blood sampling if non-breakfast eater) over the next 96 hours. Further blood and urine samples will be collected at 1, 2, 3, 5, 8, 24, 26, 48, 50, 72, 74 and 96 hours and will require participants to return to the laboratory at each of these time points. Following the first period of supplementation participants will complete a 7 day washout period in which they will not be required to attend the laboratory. Following the washout period they will repeat the supplementation period consuming the supplement they did not receive during the first period.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • apparently healthy males/females between the ages of 18-40 years

Exclusion criteria

  • underlying clinical pathology

Treatment and study plan

Montmorency cherry concentrate

Dietary Supplement

Tart Montmorency cherry juice concentrate

Primary outcomes

  1. Change in uric acid

    Time frame: 0, 1, 2, 3, 5, 8, 24, 26, 48 hours

    measurement of changes in uric acid over a 48h period

Secondary outcomes

  1. Change in C-reactive protein

    Time frame: 0,1,2,3,5,8,24,26,48 hours

    measurement of changes in c-reative protein over a 48h period

Other outcomes

  1. Change in anthocyanins, polyphenolics and creatinine

    Time frame: 0,1,2,3,5,8,24,26,48 hours

    measurement of changes in anthocyanins, polyphenolics and creatinine over a 48h period

Sponsors and collaborators

Lead sponsor

Northumbria University

Other

Registry information

Official study title

The Influence of Tart Montmorency Cherries on Indices of Uric Acid Metabolism

Important dates

Study start
2012
Primary completion
2012
Study completion
2013
First posted
Apr 5, 2013
Registry last updated
Apr 5, 2013

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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