Monocentric Randomised Controlled Trial to Assess Whether Virtual Reality Reduces the Use of Hypnotic Agents During IVF/ICSI Oocyte Retrieval

The Cp50 is defined as the median of the target concentration at which 50% of participants showed movement during the oocyte puncture procedure. Any difference between the two groups will be determined using Dixon's up and down technique

The participant's anxiety was measured prior to the study. It was assessed using the STAI questionnaire in order to define the general state of anxiety (STRAI) and the level of immediate anxiety in relation to the examination (STATE). This is a two-part questionnaire with around thirty questions in each section, for which a single response is used to describe the intensity of the relationship: very often, often, rarely, never. An anxiety VAS will be requested at the time of the WHO checklist, together with the intensity of any pain. These questions will be asked again in the intensive care unit when the patient is put in the standing position.

Tolerance of the device and the audiovisual distraction session is defined by the occurrence of undesirable effects (dizziness, nausea, headaches). This is done using a 4-level scale for each item (none, mild, moderate, severe).

The intensity of pain on propofol injection was assessed using a three-point behavioural scale for facial expression (0: none, 1: frown, or 2: grimace), verbal response (0: none, 1: groan, or 2: clear expression of pain) and attempt to withdraw the arm (0: none, 1: medium, or 2: strong). The discomfort scale is the sum of these three clinical parameters and therefore ranges from 0 to 6.

Any complications linked to anaesthesia from induction to recovery are collected:

• Number of events with arterial oxygen desaturation below 92%,
• Number of episodes with a ventilatory frequency of less than 10 cycles/min,
• Occurrence of bronchospasm.

Time to street readiness will be assessed using the CHUNG

Acceptance of audiovisual distraction by anaesthetists, gynaecologists and nursers will be assessed using a 4-level scale (very satisfied, satisfied, partially satisfied, not satisfied) and by collecting reasons for not being satisfied (partially satisfied, not satisfied) (short open answers).

Participant satisfaction is assessed on leaving the post-interventional monitoring room using a 4-level scale (very satisfied, satisfied, partially satisfied, not satisfied), with a free text provided in addition. Any interruption of the audiovisual distraction session at the participant's request will be noted. Satisfaction with the procedure may also be obtained from healthcare professionals.

Resumption of activities of daily living was assessed during the next day's telephone call using a subjective numerical rating scale ranging from 0 (bedridden) to 10 (full recovery).

Post-intervention monitoring room discharge time is defined as the time between the end of the operation and the achievement of an ALDRETE score of 10.