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OpenTrials
Completed

NCT Number: NCT04937361

Monitoring of MDRO Dynamics and Resistance Mechanisms in a University Hospital Network

Survey on the prevalence of MDRO to monitor the import of MDRO from the community. Rectal swabs will be taken and cultivated. Survey on community-onset and nosocomial bloodstream infections will be documented and strains will be isolated. For each BSI a clinical data set will be obtained (e.g. patient age, gender, date of hospitalization, antibiotic therapy). Genetic analysis of MDRO from the prevalence and BSI study. In a subset of patients the microbiome-resistome interactome will be analysed in more detail. Furthermore, the impact of infection control measures due to the Covid-19 pandemic on nosocomial BSI will be investigated.

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Key information

Conditions

MDRO

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Klinik für Infektiologie und Mikrobiologie

Lübeck, Germany

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • at least 18 years old
  • informed consent
  • inpatient

Exclusion criteria

  • less than 18 years old
  • Not capable of giving informed consent
  • outpatient

Treatment and study plan

Rectal Swab

Other

collection of rectal swabs

Primary outcomes

  1. monitoring of MDRO prevalence

    Time frame: at hospital admission

    obtain a better understanding for the emergence of resistance within the microenvironment under selective pressure

  2. monitoring of blood stream infections

    Time frame: during hospitalization, up to 4 weeks

    obtain a better understanding for the emergence of resistance within the microenvironment under selective pressure

  3. integrate novel techniques for microbiome-resistome interaction analysis

    Time frame: through study completion, after 4 years

    obtain a better understanding for the emergence of resistance within the microenvironment under selective pressure

Sponsors and collaborators

Lead sponsor

University of Luebeck

Other

Collaborators

  • University Hospital Freiburg
  • University Hospital Tuebingen
  • University Hospital of Berlin
  • University Hospital of Cologne
  • University of Giessen

Registry information

Acronym: R-Net

Important dates

Study start
2021
Primary completion
2025
Study completion
2025
First posted
Jun 24, 2021
Registry last updated
May 6, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.